Design development and optimization of immediate release tablet of valsartan

  • Abhimanyu Rai Sharma Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Birendra Shrivastava School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Anurag Bhargava Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Shailesh Sharma Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India
  • Binu Raina Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Prabhjot Singh Bajwa Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Abstract

The objective of the present study was to prepare immediate release tablets (IRTs) of valsartan by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary trial batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di-Sol. Attempts were also made to prepare the tablets containing superdisintegrants in combination and these resulted in the formulation with improved values of disintegration time and friability. On the basis of preliminary studies optimization of IRT was done employing 32 full factorial design using design expert 7. The optimized batch of IRTs showed friability and disintegration time values of 0.82 ± 0.07 and 29 ± 1 respectively. The percent release was also found to be 94.73 ± 4.97% in 5 min.


Keywords: Immediate release tablets, Valsartan, Hypertension, Sodium starch glycolate, Ac-Di-Sol, 32 full factorial design

Downloads

Download data is not yet available.

Author Biographies

Abhimanyu Rai Sharma, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Birendra Shrivastava, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

Anurag Bhargava, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Shailesh Sharma, Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India

Binu Raina, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Prabhjot Singh Bajwa, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

References

1. Setty CM, Prasad DVK, Gupta VRM, Sa B. Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants. Indian J Pharm Sci. 2008; 70(2):180-184
2. DRUG Clarke's Analysis of Drugs and Poisons, Third Edition
3. Rai. V. K., Pathak. N., Bhaskar. R., Nandi. B. C., Dey. S., Tyagi. L. K., Optimization of immediate release tablet of raloxifene hydrochloride by wet granultion method. Int J Pharm Sci Drug Res. 2009 ; (1):51-54
4. The United States Pharmacopoeia-27/National Formulary-22, 2004, Asian edition. Rockville, MD:US Pharmacopoeial Convention. Inc 2648-2649
5. Raina B, Sharma A, Bajwa PS. Formulation evaluation and optimization of fast disintegrating tablet of ketorolac tromethamine. Journal of pharmaceutical investigation.2017; 1-1
6. United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 1432
7. United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 483
8. Jain CP, Naruka PS. Formulation and evaluation of fast dissolving tablets of valsartan. Int J Pharm Pharm Sci. 2009; 1(1):219-26.
9. United State Pharmacopoeia/NF, 38/33 United Pharmacopoeial Convention Inc. Rockville, p 486
10. Shrivastava AR, Ursekar B, Kapadia CJ. Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets. Current drug delivery. 2009; 6(1):28-37.
11. Banker GS, Anderson NR. Lachman L, Lieberman HA, Kanig JL (1987) Tablets. The theory and practice of industrial pharmacy, 3rd edn. Varghese Publishing House, Mumbai, p 296
12. Beringer P, Marderosian AD, Felton L, Gelone S, Gennaro AR, Gupta PK, Hoover JE (2005) Oral solid dosage form, 21st edn. vol 1, The Science and Practice of Pharmacy, Remington, pp 917–918
Statistics
18 Views | 19 Downloads
How to Cite
Sharma, A. R., Shrivastava, B., Bhargava, A., Sharma, S., Raina, B., & Bajwa, P. S. (2019). Design development and optimization of immediate release tablet of valsartan. Journal of Drug Delivery and Therapeutics, 9(2-s), 43-47. https://doi.org/10.22270/jddt.v9i2-s.2444