Pharmacological activities of aqueous flower extract of Ixora coccinea L.

  • Chandrasekaran Sivaraj ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032
  • Adaikkalasamy Jenifer Kumaraguru College of Technology, Coimbatore, Chennai-641 049
  • Krishna Saraswathi ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032
  • Perumal Arumugam ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

Abstract

Nature has blessed the universe with plenty of medicinal plants, so often referred as the Medicinal Garden of the world. In Indian Vedas, the medicinal plants including every part of the plant from roots to flowers were used for curing several diseases. Therefore, it is necessary to enrich the dietary system with antioxidant molecules to protect the human system against various diseases. The aim of the study was to evaluate antioxidant, anti-inflammatory, antibacterial and antidiabetic activities of aqueous flowers extract of Ixora coccinea belongs to the family Rubiaceae. Antioxidant activities such as DPPH· radical, superoxide (O2.-) radical scavenging activities, phosphomolybdenum reduction and Fe3+ reducing power activities were carried out. The IC50 of DPPH· radical and superoxide (O2.-) radical were 13.58 and 23.51 µg/mL concentrations. The RC50 of phosphomolybednum reduction and Fe3+ reduction were 20.57 and 14.57 µg/mL concentrations. The IC50 of haemolytic inhibition was 99.72 µg/mL concentration. Total phenolic and flavonoid content were 369.1 µg/mg Gallic acid equivalents and 55.14 µg/mg Quercetin equivalents. The IC50 of alpha amylase enzyme inhibition was 655.02 µg/mL concentration. The antibacterial activity showed maximum zone of inhibition of 15mm for B. subtilis at 500 µg/mL concentration.


Keywords: Antioxidant, DPPH· radical, Superoxide (O2.-) radical, alpha-amylase, haemolysis.

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Author Biographies

Chandrasekaran Sivaraj, ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

Adaikkalasamy Jenifer, Kumaraguru College of Technology, Coimbatore, Chennai-641 049

Kumaraguru College of Technology, Coimbatore, Chennai-641 049

Krishna Saraswathi, ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

Perumal Arumugam, ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

ARMATS Biotek Training and Research Institute, Guindy, Chennai-600 032

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How to Cite
Sivaraj, C., Jenifer, A., Saraswathi, K., & Arumugam, P. (2019). Pharmacological activities of aqueous flower extract of Ixora coccinea L. Journal of Drug Delivery and Therapeutics, 9(2-s), 28-34. https://doi.org/10.22270/jddt.v9i2-s.2440