Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

  • Stanekzai Azimullah Research Scholar, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab and Lecturer at Kabul University, Faculty of Pharmacy, Deportment of Pharmaceutics.
  • , Vikrant Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.
  • CK Sudhakar Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.
  • Pankaj Kumar Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.
  • Akshay Patil Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India
  • Md. Rageeb Md. Usman Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India
  • Mohammed Zuber Shaikh Usman RFNS, Senior Science College, Akkalkuwa, District Nandurbar, Maharashtra, India
  • Bharat V. Jain

Abstract

Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Techniques like high-pressure homogenization, wet milling, emulsification, solvent evaporation, bottom up technology and top down technology have been applicable in the fabrication of nanosuspensions. Nanosuspension delivery is possible by several routes, such as oral, pulmonary, parenteral and ocular routes. Nanosuspension not only solves solubility and bioavailability issue, but improve drug safety and efficacy. In this context, we reviewed the current techniques used to develop nanosuspensions and their recents studies application in drug delivery system.


Keywords : Solubility, fabrication, Characterization, Applications, Nanosuspension.

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Author Biographies

Stanekzai Azimullah, Research Scholar, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab and Lecturer at Kabul University, Faculty of Pharmacy, Deportment of Pharmaceutics.

 Research Scholar, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab and Lecturer at Kabul University, Faculty of Pharmacy, Deportment of Pharmaceutics.

, Vikrant, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

CK Sudhakar, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

Pankaj Kumar, Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

Lovely Institute of Technology (Pharmacy) School of Pharmaceutical Sciences Lovely Professional University Phagwara, Punjab.

Akshay Patil, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Md. Rageeb Md. Usman, Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

Mohammed Zuber Shaikh Usman, RFNS, Senior Science College, Akkalkuwa, District Nandurbar, Maharashtra, India

RFNS, Senior Science College, Akkalkuwa, District Nandurbar, Maharashtra, India

Bharat V. Jain

Smt. S. S. Patil College of Pharmacy, Chopda, Maharashtra, India

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Azimullah S, Vikrant , Sudhakar C, Kumar P, Patil A, Md. Usman MR, Shaikh Usman MZ, Jain BV. Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update. JDDT [Internet]. 20Mar.2019 [cited 18Jan.2021];9(2):574-82. Available from: http://jddtonline.info/index.php/jddt/article/view/2436

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