Development of Tizanidine HCl transdermal patches: In-vitro and Ex-vivo characterization

  • Dr. Shayeda University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana State
  • Nusrat Ayesha University College of pharmaceutical sciences, kakatiya university,Warangal,Telangana state.

Abstract

The purpose of this work was to design and evaluate matrix type transdermal patches of Tizanidine hydrochloride using Hypromellose (HPMC E15) as polymer, dibutyl phthalate as plasticizer and citral as permeation enhancer. The DSC and FTIR results showed the compatibility of the excipients with the drug. These transdermal drug delivery systems were characterized for their thickness, folding endurance, content uniformity, tensile strength and in-vitro release studies of the drug from the polymeric matrix. In-vitro release studies and ex-vivo permeation were carried out with modified Franz diffusion cell using pH 5.8 & pH 7.4 phosphate buffers as receptor medium and it showed controlled release of drug. The results suggest that the formulation of TIZ may be useful in the development of a therapeutic system to deliver TIZ across the skin for a prolonged period, i.e. 24 hr.


Keywords: Tizanidine Hydrochloride, Transdermal patch, HPMC E15, in-vitro & ex-vivo.

Downloads

Download data is not yet available.

Author Biographies

Dr. Shayeda, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana State

University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana State

Nusrat Ayesha, University College of pharmaceutical sciences, kakatiya university,Warangal,Telangana state.

University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana State

References

1. Ahlam Zaid Alkilani, Maelíosa T.C.McCrudden and Ryan F. Donnelly, Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum; Pharmaceutics J, 2015; 7:438-470.
2. Arun Raj R, Formulation Evaluation And In Vitro Permeation Studies Of Transdermal Nifedipine From Matrix Type Patches, International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6(1):185-188.
3. Asha Das, Abdul Baquee Ahmed, Formulation And Evaluation Of Transdermal Patch Of Indomethacin Containing Patchouli Oil As Natural Penetration Enhancer, Asian Journal of Pharmaceutical and Clinical Research,2017; 10(11):320-325.
4. Donbrow M, Samuelov Y, J. Pharm. Pharmacol, 1980; 32:463-470.
5. Shingade G, Review on: recent trend on transdermal drug delivery system. Journal of Drug Delivery and Therapeutics, 2012; 2(1):66-75.
6. Higuchi T, J. Pharm. Sci, 1963; 52(12):1145-1149.
7. Jun Chen, Qiu-Dong Jiang, Ya-Ping Chai, Hui Zhang, Pei Peng and Xi-Xiong Yang, Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery, Molecules J, 2016; 21:1709,1-22.
8. Rahman SAU, & Sharma N, Formulation and evaluation of matrix transdermal patches of glibenclamide. Journal of Drug Delivery and Therapeutics, 2018; 8(5-s):366-371.
9. Kusum Devi V, Saisivam S, Maria G.R, Deepti P.U, Drug Dev. Ind. Pharm, 2003; 29:495-503.
10. Nuntakan Suwanpiodokkul, Phensri Thongnopnua, Kaisri Umprayan, AAPS Pharm. SciTech, 2004; 5(48):1-7.
11. Peltola S, Saarinen-Savolainen P, Kiesvaara J, Scihonen T.M, Urtti A, Int. J. Pharm, 2003; 254:99-107.
12. Ramesh Gannu, Vamshi Vishnu Y, Kishan V and Madhusudan Rao Y; Development of Nitrendipine Transdermal Patches: In vitro and Ex vivo Characterization, Current Drug Delivery, 2007; 4:69-76.
13. Robinson J.R, Lee V.H, 1987, Controlled Drug Delivery: Fundamentals and Applications, Marcel Dekker, New York, 523-552.
14. Wagner J.G, J. Pharm. Sci, 1969; 58:1253-1257.
Statistics
96 Views | 137 Downloads
How to Cite
Shayeda, D., & Ayesha, N. (2019). Development of Tizanidine HCl transdermal patches: In-vitro and Ex-vivo characterization. Journal of Drug Delivery and Therapeutics, 9(1-s), 295-300. https://doi.org/10.22270/jddt.v9i1-s.2431