Evaluation of hair growth promoting activity of petroleum ether extract of Abrus precatorius Linn. on Wistar Albino rats

  • Namrata Omhare Smriti College of Pharmaceutical Education, Indore-452010, M.P., india
  • Pratibha Sahu Smriti College of Pharmaceutical Education, Indore-452010, M.P., india
  • Shailee Gautam Smriti College of Pharmaceutical Education, Indore-452010, M.P., india
  • Nidhi Jain VNS College of Pharmacy, Bhopal-462044, M.P., India

Abstract

In present investigation was carried out to screening of hair growth promoting potentiality of petroleum ether extract of Abrus precatorius leaf. Preliminary chemical tests and TLC analysis revealed the presence flavonoids and saponins. Hair growth promoting activity of petroleum ether of Abrus precatorius was screened by considering different parameters which included time taken for covering bald patch, length of hair produced, percentage of hair follicles in anagen and telogen phases, time of hair growth initiation and completion and level of minerals in blood. The petroleum ether extract of Abrus precatorius showed a very good hair growth promoting activity at a dose of 300 mg/kg which was comparable to that of 2% minoxidil. After 30 days of treatment with test and standard drugs it was observed that, time taken for covering the bald patch, hair growth initiation and completion time and quantitative hair growth were found to be comparable to that of the standard drug. An increase in percentage of hair follicles turning from telogen phase to anagen phase was noted. The control treated group of animals showed poor hair growth for all the parameters.


Keywords: Abrus precatorius Linn, Anagen, Catagen, Telogen, Minoxidil

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Author Biographies

Namrata Omhare, Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Pratibha Sahu, Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Shailee Gautam, Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Smriti College of Pharmaceutical Education, Indore-452010, M.P., india

Nidhi Jain, VNS College of Pharmacy, Bhopal-462044, M.P., India

VNS College of Pharmacy, Bhopal-462044, M.P., India

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How to Cite
1.
Omhare N, Sahu P, Gautam S, Jain N. Evaluation of hair growth promoting activity of petroleum ether extract of Abrus precatorius Linn. on Wistar Albino rats. JDDT [Internet]. 15Mar.2019 [cited 30Nov.2020];9(2):330-5. Available from: http://jddtonline.info/index.php/jddt/article/view/2426