Synthesis, in-vitro characterization and pharmacological evaluation of conjugates of flurbiprofen and polysaccharides for colon specific drug delivery

  • P Soni School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India
  • K Soni School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India
  • GP Choudhary School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

Abstract

The aim of the study was to prepare site specific drug delivery of flurbiprofen using polysaccharides by the formation of glycosidic linkage which is hydrolysed by the microflora present in colon. This approach prevents drug release in the upper gastrointestinal environment. Due to the minimal degradation of conjugates in upper Git, the in vitro drug release in SGF, SIF and SCF was found upto 4.26±0.03%, 12.41±0.08% and 92.72±3.33% respectively.


Keywords: Colon specific drug delivery, Conjugates, Flurbiprofen, Microbial system.

Downloads

Download data is not yet available.

Author Biographies

P Soni, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

K Soni, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

GP Choudhary, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (MP), India

Statistics
63 Views | 115 Downloads
How to Cite
Soni, P., Soni, K., & Choudhary, G. (2019). Synthesis, in-vitro characterization and pharmacological evaluation of conjugates of flurbiprofen and polysaccharides for colon specific drug delivery. Journal of Drug Delivery and Therapeutics, 9(2), 316-320. https://doi.org/10.22270/jddt.v9i2.2425