Formulation and development of some BCS Class II drugs

  • SC Marapur Dept. of Pharmaceutics, BLDEA’s SSM College of Pharmacy and Research centre, Vijayapur-586 103, Karnataka, India.
  • Rakesh Kumar Jat Dept. of Pharmaceutical Science, JJT University Rajasthan
  • J S Patil Department of Pharmaceutics, VT’ Shivajirao S. Jondhle College of Pharmacy, Thane, Maharashtra, India

Abstract

The aim of this research was to develop and evaluate liquisolid compacts of Ezetimibe a bcs class II drug. The series of formulations containing Ezetimibe drug were formulated by using aerosil a colloidal silicone dioxide and avicel PH microcrystalline cellulose in different ratios by using suitable solvent. Solubility studies were performed in propylene glycol and polyethylene glycol (PEG-200, 400, 600) for the choice of the best non volatile liquid to dissolve Ezetimibe. On the basis of the solubility data PG was chosen as a good solvent for the Ezetimibe. Ezetimibe was dissolved in solvent PG for the preparation of solution of drug. The coating and carrier materials transferred to the drug solution and added 5% of disintegrating agent (Croscarmellose) was mixed completely and the blend is compressed into compacts. Formulated compacts were evaluated for all post compression parameters and the in-vitro drug release study was carried out. All the formulations have shown a very good drug release in  15 min except compressibility problems due to higher812 loading factor of liquid vehicle for the formulations. The selected formulation F11 containing 30% of drug solution has  shown good drug release of 100.01% in 15  min compared to dissolution of  pure drug and marketed tablet which shown 45.5%  and 81.6 % respectively.No interactions were found  between drug and polymers in FITR as well as DSC. XRD of selected formulation shows that drug present in the formulation is in amorphous form.


Keywords: Ezetimibe HCl, Avicel PH, Aerosil 200, Propylene glycol, liquisolid compacts

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Author Biographies

SC Marapur, Dept. of Pharmaceutics, BLDEA’s SSM College of Pharmacy and Research centre, Vijayapur-586 103, Karnataka, India.

Dept. of Pharmaceutics, BLDEA’s SSM College of Pharmacy and Research centre, Vijayapur-586 103, Karnataka, India.

Rakesh Kumar Jat, Dept. of Pharmaceutical Science, JJT University Rajasthan

Dept. of Pharmaceutical Science, JJT University Rajasthan

J S Patil, Department of Pharmaceutics, VT’ Shivajirao S. Jondhle College of Pharmacy, Thane, Maharashtra, India

Department of Pharmaceutics, VT’ Shivajirao S. Jondhle College of Pharmacy, Thane, Maharashtra, India

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How to Cite
Marapur, S., Jat, R., & Patil, J. S. (2019). Formulation and development of some BCS Class II drugs. Journal of Drug Delivery and Therapeutics, 9(2), 321-329. https://doi.org/10.22270/jddt.v9i2.2424