Design, development and optimization of immediate release tablet of deflazacort

  • Binu Raina NRI Institute of Pharmaceutical Sciences, bhopal (M.P), IndiaCh. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Birendra C Shrivastava School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India,
  • Anurag Bhargava Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Shailesh Sharma Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India
  • Abhimanyu Rai Sharma Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Prabhjot Singh Bajwa Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Abstract

The objective of the present study was to prepare immediate release tablets (IRTs) of deflazacort by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di-Sol. Attempts were also made to prepare the tablets containing superdisintegrants in combination and these resulted in the formulation with improved values of disintegration time and friability. On the basis of preliminary studies optimization of IRT was done employing 32 full factorial design using design expert 7. The optimized batch of IRTs showed friability and disintegration time values of 0.598 and 64.17±3.50 respectively. It was also found that 96.26±1.82% of drug was released within 5 min.


Keywords: Immediate release tablets, deflazacort, Rheumatoid arthritis, Sodium starch glycolate, Ac-Di-Sol, 32 full factorial design

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Author Biographies

Binu Raina, NRI Institute of Pharmaceutical Sciences, bhopal (M.P), IndiaCh. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Birendra C Shrivastava, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India,

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India,

Anurag Bhargava, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Shailesh Sharma, Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Punjab, India

Abhimanyu Rai Sharma, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Prabhjot Singh Bajwa, Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

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How to Cite
Raina, B., Shrivastava, B., Bhargava, A., Sharma, S., Sharma, A. R., & Bajwa, P. S. (2019). Design, development and optimization of immediate release tablet of deflazacort. Journal of Drug Delivery and Therapeutics, 9(2), 250-254. https://doi.org/10.22270/jddt.v9i2.2411

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