Evaluation of Anticonvulsant and Antioxidant Activity of Senna occidentalis Seeds Extracts
Aim: The aim of present work was to determine the anticonvulsant and antioxidant activity of Senna occidentalis L. ethanolic seed extract by different models. Methods: For evaluation of anticonvulsant activity, Pentylenetetrazole (PTZ) seizure model and Maximal electroshock (MES) seizure model were used. For antioxidant activity, (1, 1-diphenyl - 2-picryl hydrazine (DPPH) and hydrogen peroxide (H2O2) method were used. Results: The finding suggested that the ethanolic extract (EAE) of Senna occidentalis in the dose 400 mg/kg body weight posses potent anticonvulsant activity. The EAE showed anticonvulsant action in dose dependent fashion. It was observed that upon increasing the concentration of extract, it showed reduced absorbance and increased free radical inhibition, and when comparison was made with Ascorbic acid, it showed marked antioxidant property in DPPH as well as H2O2 method. The IC50 of Ascorbic acid and EAE by DPPH method were found to be 14.56 and 14.8 respectively whereas the IC50 of Ascorbic acid and EAE by H2O2 method were found that 14.3and 14.8 respectively. Conclusion: The results of the present study concluded hat the EAE of Senna occidentalis L. possesses significant antioxidant and anticonvulsant activity. The activity was in dose dependent fashion. This study will assist in future research associated with formulation development of seeds of Senna occidentalis L.
Keyword: Senna occidentalis L., Anticonvulsant, Antioxidant, DPPH model
2. Sini KR, Sinha BN, Karpakavalli M, Sangeetha PT. Analgesic and antipyretic activity of Senna occidentalis Linn. Annals of Biological Research. 2011; 2 (1):195-200.
3. Hong N, Van TN, Quan VV. Effect of Extraction Solvents and Drying Methods on the Physicochemical and Antioxidant Properties of Helicteres hirsuta Lour. Leaves. 2015; 3:285-301
4. Shyamjith M, Deepa B, Anu E Joy and Rao S N. Anticonvulsant Activity of Phyllanthus Amarusin Experimentalanimal Models. International Journal of Applied Biology and Pharmaceutical Technology. 2011; 2(4):144-149.
5. Joshi R, Reeta KH, Sharma SK, Tripathi M, Gupta YK. Pharmacodynamic and pharmacokinetic interaction of Panchagavya Ghrita with phenytoin and carbamazepine in maximal electroshock induced seizures in rats. Ayu. 2015; 36: 196–202.
6. Chauhan A.K, Dobhal M.P, Joshi B.C., A review of medicinal plants showing anticonvulsant activity, Journal of Ethnopharmacology, 1988, 22:11–23.
7. McNamara JO., Drugs effective in the therapy of the epilepsies: In: Goodman and Gillman’s “The pharmacological basis of therapeutics”, McGraw-Hill, New York, 2001, 521-539.
8. Pandey MM, Vijayakumar M, Rastogi S, Rawat AKS. Phenolic content and antioxidant properties of selected Indian spices of Apiaceae. J Herb, Spice Med Plant 2012; 18:246-56.
9. Ebrahimzadeh AM, Nabavi SM, Nabavi SF, Bahramiyan F, Bekhradni AR. Antioxidant and Free Radical Scavenging Activity of H. Officinalis L. angustifolius, V. odorata, B. hyrcana and C. speciosum. Pakistan Journal of Pharmaceutical Science.2010; 23(1):29-34.
10. Furuta, S., I. Suda, Y. Nishiba and O. Yamakaw. High tertbutylperoxy radic al scavenging activities of sweet potato cultivars with purple flesh. Food Sci., Technol. 1998; 4:33-35.
11. Zahin M, Aqil F, Ahmad I. Broad spectrum antimutagenic activity of antioxidant active fraction of Punica granatum L. peel extracts. Mutat Res. 2010; 703:99–107.
12. Zidane H, Elmiz M, Aouinti F, Tahani A, Wathelet J, Sindic M, Elbachiri A. Chemical composition and antioxidant activity of essential oil, various organic extracts of Cistus ladanifer and Cistus libanotis growing in Eastern Morocco. African J. of Biotechnology, 2013; 34(12): 5314-5320.
13. Tepe B., Sokmen M., Akpulat H.A., Sokmen A. Screening of the antioxidant potentials of six Salvia species from Turkey. Food Chem.2006; 95:200-204
14. Jain S. The role of epilepsy management guidelines in a developing country. Neurology Asia 2011; 16:57-8
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