DESIGN AND EVALUATION OF TRANSDERMAL FILMS CONTAINING KETOPROFEN FOR THE TREATMENT OF ARTHRITIS
Transdermal drug delivery systems of ketoprofen have been formulated using solvent casting method. Monolithic and membrane controlled systems were prepared by using Hydroxy propyl methyl cellulose (HPMC)Â and ethyl cellulose (EC)Â polymers by incorporation glycerin and dibutyl phthalate as plasticizers respectively. Drug polymer interactions were studied by FT-IR and differential scanning calorimetry which showed no interaction between drug and the polymers used. All the patches were uniform with respect to physico-chemical evaluation. The drug uniformity in the patch was observed by scanning electron microscopy which showed uniform distribution of drug throughout the patch. The in vitro drug release studies indicated that HPMC and EC patches with no permeation enhancer released the drug in an optimum rate. The various permeation parameters such as flux, permeability co-efficient, enhancement ration and diffusion rate constants were determined for all the formulations. The effect of permeation enhancer on the diffusion of ketoprofen across rat skin was determined. The maximum flux of 9.52x10-2 mg/cm2/hr was observed with HPMC monolithic system containing 5% v/v d-limonene. A significant improvement of flux was observed with 5% d-limonene than that of 20% oleic acid. The in vitro release studies revealed that the release was sustained upto 24 hr and followed zero order kinetics.Keywords: Ketoprofen, HPMC, EC, d-limonene and Oleic acid.
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