METHYLATION PROFILING OF TUMOR SUPPRESSOR GENES INVOLVED IN LUNG CANCER
The causes of cancer are due to mutations of key proteins involved in cell cycle regulation, DNA repair enzymes and in some cases inactivation of tumor suppressor genes leads to the growth of tumors. The expression rates of TSGs vary in different stages of cancer as well in various cases of cancers. The inhibitions of TSGs are due to methylation of the DNA. In our present study, we found the genes which are methylated in different types of lung cancers and identified the methylation frequencies. Using the pubmeth database, we have identified the total number of genes undergoing methylation in the various lung cancers. From the total number of genes, we have identified the tumor suppressor genes which are in the methylated state leading to the inactivation of expression and promoting the tumor growth. The further focus on tumor suppressor genes which are methylated is necessary to find a novel way to activate them in the cancerous stage.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).