METHYLATION PROFILING OF TUMOR SUPPRESSOR GENES INVOLVED IN LUNG CANCER
Abstract
The causes of cancer are due to mutations of key proteins involved in cell cycle regulation, DNA repair enzymes and in some cases inactivation of tumor suppressor genes leads to the growth of tumors. The expression rates of TSGs vary in different stages of cancer as well in various cases of cancers. The inhibitions of TSGs are due to methylation of the DNA. In our present study, we found the genes which are methylated in different types of lung cancers and identified the methylation frequencies. Using the pubmeth database, we have identified the total number of genes undergoing methylation in the various lung cancers. From the total number of genes, we have identified the tumor suppressor genes which are in the methylated state leading to the inactivation of expression and promoting the tumor growth. The further focus on tumor suppressor genes which are methylated is necessary to find a novel way to activate them in the cancerous stage.
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