Development, characterization and evaluation of poly-herbal ointment and Gel formulation containing Nerium Indicum Mill, Artocarpus Heterophyllus Lam, Murraya Koenigii Linn, Punica Granatum Linn

  • Renuka Shukla SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India
  • Varsha Kashaw SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

Abstract

Objective: The objective of present study was the development, characterization and evaluation of poly-herbal ointment and gel formulations of Nerium Indicum Mill, Artocarpus Heterophyllus Lam, Murraya Koenigii Linn, Punica Granatum Linn extract. Plant derived substances and herbal medicines have recently attracted the great interest towards their versatile application. Medicinal plants are the richest source of bioactive compounds used in traditional and modern medicine. The ointment and gel formulation of plant extract has a sound approach, The poly-herbal ointment and gel formulation were evaluated for its physicochemical parameters like color, odour, pH, spreadability, extrudability, consistency, diffusibility, solubility, washability, non-irritancy and stability. Materials and methods: Extract of all four plants has been separated by the soxhlet extraction by 70% ethanol. Poly-herbal ointment and gel formulation has been prepared by mixing the extract of Nerium Indicum Mill, Artocarpus Heterophyllus Lam, Murraya Koenigii Linn, Punica Granatum Linn with carbapol 940 for Gel formulation and PEG 2000 & PEG 600 for ointment formulation. Results and conclusion: Physicochemical evaluation shows that the poly-herbal ointment and gel formulations fulfilled the criteria as herbal formulation and irritancy test also performed to indicate the effectiveness and efficacy of prepared ointment and gel formulations. The poly-herbal ointment and gel formulations were also evaluated for its stability at various temperature conditions which shows no change in the irritancy, spreadability and diffusion study. Thus it could become a medium to use the medicinal properties of extracts effectively and easily as a simple dosage form.


Keywords:  Nerium Indicum Mill, Artocarpus Heterophyllus Lam, Murraya Koenigii Linn, Punica Granatum Linn, extract, ointment, gel.     

Downloads

Download data is not yet available.

Author Biographies

Renuka Shukla, SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

Varsha Kashaw, SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar, Madhya Pradesh, India

References

1. Elevitch CE, Manner HI. Artocarpus heterophyllus (jackfruit). Species Profiles for Pacific Island Agroforestry 2006; 10:1-25.
2. Akhilhari H, Revikumar KG, Divya D. Artocarpus. A Review of its Phyto-chemistry and Pharmacology. Journal of Pharma Search. 2014; 9(1):7-13.
3. Bakar MF, Abdul Karim F, Perisamy E. Comparison of phytochemicals and antioxidant properties of different fruit parts of selected Artocarpus species from Sabah, Malaysia. Sains Malays. 2015; 44(3):355–363.
4. Ojwang RA, Muge EK, Mbatia BN, Mwanza BK, Ogoyi DO. Compositional, elemental, phytochemical and antioxidant characterization of Jackfruit (Artocarpus heterophyllus) Pulps and Seeds from Selected Regions in Kenya and Uganda. European Journal of Medical physics. 2018; 23(3):1-12.
5. Mohammed HPM, Rashid K, Senthil CK. 2018. Artrocarpus Heterophyllus- review study on Potential Activity. Journal of Tropical Biology and Conservation. 2018; 15:61-80.
6. Burci LM, Silva CB, Rondon JN, Silva LM, Sergio FA, Miguel OG, Dias JFG, Miguel MD. Acute and subacute (28 days) toxicity, hemolytic and cytotoxic effect of Artocarpus heterophyllus seed extracts. 2018. Toxicology Reports. https,//doi.org/10.1016 /j.toxrep.2018.02.006.
7. Nagargoje AN, Phad SS. A Review on phytochemistry and pharmacology of Nerium indicum Mill. Plant. International Journal of Pharmaceutical Sciences Review. 2003; 21(2):148-151.
8. Dey P, Chaudhuri TK. Pharmacological aspects of Nerium indicum Mill, A comprehensive review. Pharmacognosy Review 2014; 8(16):156-162.
9. Singh S, More PK, Mohan SM. Curry leaves (Murraya koenigii Linn. Sprengal )-a miracle plant. Indian Journal of Scientific Research. 2014; 4:46-52.
10. Sharma P, Mohan L and Shrivastava CN. Larvicidal potential of Nerium indicum and Thuja oriertelis extracts against malaria and Japanese encephalitis vector. Journal of environmental biology. 2005; 26(4):657-660.
11. Rajendran MP, Pallaiyan BB, Selvaraj N. Chemical composition, antibacterial and antioxidant profile of essential oil from Murraya koenigii (L.) leaves. Avicenna J Phytomed. 2014; 4(3):200-214.
12. Salomi MV, Manimekalai R. Phytochemical analysis and antimicrobial activity of four different extracts from the leaves of Murraya Koenigii. International Journal of Current Microbiololgy Applicable Science. 2005; 70:875-882
13. Jadhav VS, Ghawate VB. Evaluation of combined wound healing activity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthes arbortristis on rats. Drug Invention Today. 2017; 9(2):24-27.
14. Nayak SB, Rodrigues Y, Maharaj S, Bhogadi VS. Wound healing activity of the fruit skin of Punica granatum. Journal of Med Food.2013; 16(9):124-126.
15. Shirote PJ, Deepali SS, Thorat SS. Isolation, phytochemical screening and biological evaluation of Punica granatum leaves extract. European Journal of Pharmaceutical and Medical Research. 2018; 5(7):271-275.
16. Sangeetha R, Jayaprakash A. Phytochemical Screening of Punica granatum Linn. Peel Extracts. Journal of Academic and Industrial Research. 2015; 4:160-162.
17. Mansourian A, Boojarpour N, Ashnagar S, Bejtollahi JM, Shamshiri AR. The comparative study of antifungal activity of Syzygium aromaticum, Punica granatum and nystatin on Candida albicans-an in-vitro study. 2014; 24(4):163-168.
18. Li Y, Yang F, Zheng W. Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in nonsmall cell lung cancer in vitro. Biomed Pharmacother. 2016; 80:227-35.
19. Redha AA, Hasan AM, Mandeel Q. Phytochemical Determinations of Pomegranate (Punica granatum) Rind and Aril Extracts and their Antioxidant, Antidiabetic and Antibacterial Activity. Nat Prod Chem Res. 2018; 64:15-20.
20. Amer OSO, Dkhil MA, Hikal WM, Al Quraishy S. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice. Bio Med Research International. 2015; 2015:219670.
21. Shubhangi ES, Monali DT. Formulation and evaluation of herbal ointment containing Neem and Turmeric extract. Journal of Scientific and Innovative Research. 2016; 5(4):149-151.
22. Asija R, Dhaker PC, Nema N. Formulation & evaluation of voriconazole ointment for topical delivery. Journal of Drug Discovery and Therapeutics. 2015; 26(3):7-14.
23. Sawant SE, Tajane MD. Formulation and evaluation of herbal ointment containing Neem and Turmeric extract. Journal of Scientific and Innovative Research. 2016; 5(4):149-151.
24. Mishra NN, Kesharwani A, Agarwal A, Polachira SK, Nair R, Gupta SK. Herbal Gel Formulation Developed for Anti-Human Immunodeficiency Virus (HIV)-1 Activity Also Inhibits In-vitro HSV-2 Infection. Viruses. 2018; 24:10(11).
25. Shahtalebi MA, Asghari GR, Rahmani F, Shafiee F, Jahanian-Najafabadi A. Formulation of Herbal Gel of Antirrhinum majus Extract and Evaluation of its Anti-Propionibacterium acne Effects. Adv Biomed Res. 2018; 7:53. doi: 10.4103/abr.abr_9_17. eCollection 2018.
26. Aslani, A, Zolfaghari, B, Fereidani, Y. Design, formulation, and evaluation of a herbal gel contains melissa, sumac, licorice, rosemary, and geranium for treatment of recurrent labial herpes infections. Dental Research Journal. 2018; 15(3):191-200.
27. Shukla R, Kashaw V. Extraction and wound healing potential of Nerium Indicum M, Artocarpus Heterophyllus Lam, Murraya Koenigii L, Punica Granatum L on albino rats using burn wound model. Journal of Drug Delivery & Therapeutics. 2019; 9(1-s):337-346.
Statistics
100 Views | 172 Downloads
How to Cite
Shukla, R., & Kashaw, V. (2019). Development, characterization and evaluation of poly-herbal ointment and Gel formulation containing Nerium Indicum Mill, Artocarpus Heterophyllus Lam, Murraya Koenigii Linn, Punica Granatum Linn. Journal of Drug Delivery and Therapeutics, 9(2), 64-69. https://doi.org/10.22270/jddt.v9i2.2381

Most read articles by the same author(s)