FORMULATION DEVELOPMENT AND EVALUATION OF SOLID LIPID NANOPARTICLES OF ACECLOFENAC USING SOLVENT INJECTION METHOD.

  • ManMohan Kaushik
  • Govind Mohan
  • Tarkeshwar Prasad Shukla
  • Niranjan Upadhyay
  • Abhishek Mathur
  • Bismi P. Cherian

Abstract

Solid lipid nanoparticles (SLN) of aceclofenac were prepared by solvent injection method. Glyceryl behenate (Compritol 888 ATO) was used as lipid core, and Poloxamer 188 as the surfactant. Isopropyl alcohol (IPA) was used to dissolve both lipid and drug. The mean particle size measured by laser diffraction (LD) was 226.9 nm and the surface morphology was determined by scanning electron microscopy. The entrapment efficiency (EE) was found to be 90%. In-vitro dissolution was found to be 90.22%.

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Author Biographies

ManMohan Kaushik
M. Pharm. (Pharmaceutics), NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
Govind Mohan
M. Pharm., Ph.D., Principal, NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
Tarkeshwar Prasad Shukla
M. Pharm., Assistant Professor, NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
Niranjan Upadhyay
M. Pharm. (Pharmaceutics), NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
Abhishek Mathur
M. Pharm. (Pharmaceutics), NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
Bismi P. Cherian
M. Pharm. (Pharmaceutics), NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan)
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How to Cite
1.
Kaushik M, Mohan G, Shukla T, Upadhyay N, Mathur A, Cherian B. FORMULATION DEVELOPMENT AND EVALUATION OF SOLID LIPID NANOPARTICLES OF ACECLOFENAC USING SOLVENT INJECTION METHOD. JDDT [Internet]. 15Jul.2012 [cited 19Sep.2020];2(4). Available from: http://jddtonline.info/index.php/jddt/article/view/237