Molecular Characterization of Kidd Antigens Polymorphism (Jk) among Sudanese patients with Chronic Renal Failure in Khartoum State - Sudan

  • Amin Omer Abbas Department of Immunohaematology, Albakkari Polyclinic, Almadinah Almunawarah, Saudi Arabia.
  • Fathelrahman Mahdi Hassan Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan
  • Mahadi H.A. Abdulla Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan
  • Mutaz Ibrahim Hassan Faculty of Medical Laboratory Science, Shendi University - Sudan
  • Jevara Mohamed Sanhory Faculty of Medical Laboratory Science, Shendi University - Sudan
  • Salah Eldien G Elzaki Department of Molecular Epidemiology, Tropical Medicine Research Center, Khartoum, Sudan
  • Yasir Yousif Abbas Department of Blood Bank, Turkish Teaching Hospital, Khartoum, Sudan
  • Hussam Eldien Mubark Ibrahim Department of Hematology, Ibrahim Malik Teching Hospital, Khartoum, Sudan.

Abstract

Background: The Kidd glycoprotein is expressed in the kidney, where it enables the kidney to build up a high concentration of urea, which is needed for the kidney to produce concentrated urine. The urea transport across Kidd null RBC membranes is ~1000 times slower than across normal RBC membrane. Chronic kidney disease develops slowly and, initially, show few symptoms. CKD can be the long term consequence of irreversible acute disease or part of a disease progression. The most common causes of chronic renal failure are related to poorly controlled diabetes, poorly controlled high blood pressure.


Objective: the aim of this study was to assess the association between the Kidd antigen polymorphism and chronic kidney disease, in Sudan.


Results: The distribution of kidd blood group between chronic kidneydisease patient and control group were (49%) and (50%) for Jk (a + b−), 40% and 44% for Jk (a + b+) and 11% and 6% Jk (a − b+) respectively. also there were different in ten samples represented genomic typing (Jk ab ) but phenoptying represented as (Jka).


Conclusion: There were no obvious effects of  kidd antigens polymorphism on kidney function .


Keywords: Kidd blood group, Genomic typing, Phenotyping, Chronic kidney disease.

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Author Biographies

Amin Omer Abbas, Department of Immunohaematology, Albakkari Polyclinic, Almadinah Almunawarah, Saudi Arabia.

Department of Immunohaematology, Albakkari Polyclinic, Almadinah Almunawarah, Saudi Arabia.

Fathelrahman Mahdi Hassan, Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan

Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan

Mahadi H.A. Abdulla, Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan

Department of Hematology, Faculty of Medical Laboratory science, Omdurman Ahlia University, Sudan

Mutaz Ibrahim Hassan, Faculty of Medical Laboratory Science, Shendi University - Sudan

Faculty of Medical Laboratory Science, Shendi University - Sudan

Jevara Mohamed Sanhory, Faculty of Medical Laboratory Science, Shendi University - Sudan

Faculty of Medical Laboratory Science, Shendi University - Sudan

Salah Eldien G Elzaki, Department of Molecular Epidemiology, Tropical Medicine Research Center, Khartoum, Sudan

Department of Molecular Epidemiology, Tropical Medicine Research Center, Khartoum, Sudan

Yasir Yousif Abbas, Department of Blood Bank, Turkish Teaching Hospital, Khartoum, Sudan

Department of Blood Bank, Turkish Teaching Hospital, Khartoum, Sudan

Hussam Eldien Mubark Ibrahim, Department of Hematology, Ibrahim Malik Teching Hospital, Khartoum, Sudan.

Department of Hematology, Ibrahim Malik  Teching Hospital, Khartoum, Sudan.

References

Background: The Kidd glycoprotein is expressed in the kidney, where it enables the kidney to build up a high concentration of urea, which is needed for the kidney to produce concentrated urine. The urea transport across Kidd null RBC membranes is ~1000 times slower than across normal RBC membrane. Chronic kidney disease develops slowly and, initially, show few symptoms. CKD can be the long term consequence of irreversible acute disease or part of a disease progression. The most common causes of chronic renal failure are related to poorly controlled diabetes, poorly controlled high blood pressure.
Objective: the aim of this study was to assess the association between the Kidd antigen polymorphism and chronic kidney disease, in Sudan.
Results: The distribution of kidd blood group between chronic kidneydisease patient and control group were (49%) and (50%) for Jk (a + b−), 40% and 44% for Jk (a + b+) and 11% and 6% Jk (a − b+) respectively. also there were different in ten samples represented genomic typing (Jk ab ) but phenoptying represented as (Jka).
Conclusion: There were no obvious effects of kidd antigens polymorphism on kidney function .
Keywords: Kidd blood group, Genomic typing, Phenotyping, Chronic kidney disease.
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How to Cite
Abbas, A. O., Hassan, F. M., Abdulla, M. H., Hassan, M. I., Sanhory, J. M., Elzaki, S. E. G., Abbas, Y. Y., & Ibrahim, H. E. M. (2019). Molecular Characterization of Kidd Antigens Polymorphism (Jk) among Sudanese patients with Chronic Renal Failure in Khartoum State - Sudan. Journal of Drug Delivery and Therapeutics, 9(2), 25-27. https://doi.org/10.22270/jddt.v9i2.2368