Assessment of anti-oxidant activity of Ficus benghalensis leaves: an In-vitro design

  • Aditi Pedgaonkar Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Gadeela Manish Adithya Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Panyala Sandhya Reddy Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Kollu Thanuja Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Lankadasari Divyashree Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Bakshi Vasudha Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Boggula Narender Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Abstract

Background: Medicinal plants represent a rich source of natural anti-oxidants. The traditional medicine involves the use of different plant extracts of bioactive constituents. Ficus benghalensis is a large evergreen tree found throughout India. It is commonly called Banyan tree. It is used in traditional system of medicine like Ayurveda and homoeopathy. Ficus is a huge tropical deciduous or evergreen tree with more than 800 species.


Objective: Anti-oxidant effect of ethnomedicinal important plant species Ficus benghalensis (Family-Moraceae) was screened. The aim of this study was to assess the in-vitro potential of methanolic extract of Ficus benghalensis leaves as a natural anti-oxidant.


Method: Assessment of in vitro anti-oxidant activity of methanolic leaves extract of Ficus benghalensis was determined by DPPH free radical scavenging assay.


Results: The methanolic extract of Ficus benghalensis leaves demonstrates a remarkable amount of phenolic content (54 μg/ml of GAE/100gm of extract) by using Folin-ciocalteu reagent. In-vitro anti-oxidant activity of methanolic leaves extract of Ficus benghalensis was determined by DPPH free radical scavenging assay, which showed significant anti-oxidant activity compared to standard anti-oxidant (ascorbic acid). A direct correlation between total phenol and anti-oxidant activity indicates polyphenols are the main anti-oxidants.


Conclusion: These findings suggest the excellent medicinal bio-activity of Ficus benghalensis and explain the popularity of this plant in the folk medicine as a remedy for different disorders, thus supporting its folklore application as preventive remedy as an anti-oxidant. The present study shows that Ficus benghalensis leaves have radical scavenging activity and can be considered as good sources of natural anti-oxidants for medicinal and commercial uses.


Keywords: Ficus benghalensis, anti-oxidant, DPPH scavenging activity, Folin-ciocalteu reagent.

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Author Biographies

Aditi Pedgaonkar, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Gadeela Manish Adithya, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Panyala Sandhya Reddy, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Kollu Thanuja, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Lankadasari Divyashree, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Bakshi Vasudha, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Boggula Narender, Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Department of Pharmaceutical Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

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How to Cite
Pedgaonkar, A., Manish Adithya, G., Sandhya Reddy, P., Thanuja, K., Divyashree, L., Vasudha, B., & Narender, B. (2019). Assessment of anti-oxidant activity of Ficus benghalensis leaves: an In-vitro design. Journal of Drug Delivery and Therapeutics, 9(2), 20-24. https://doi.org/10.22270/jddt.v9i2.2366