Formulation and evaluation of almotriptan controlled release pellets

  • Yerikala Ramesh Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.
  • Abhilash Kaki Rohan Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.
  • Balasaradhi Koorapati Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.
  • P. Sudarsanam Department of Pharmaceutics, Seshachala College of Pharmacy, Nagari Road, Puttur – 517583, Chittoor (Dist), Andhra Pradesh, India.

Abstract

Abstract: The aim of the present study was to formulate and evaluate Almotriptan pellets. Almotriptan controlled release pellets were prepared by Solution layering technique by using croscarmellose and povidone in former case and three different polymers HPMC K 100, Ethyl cellulose and Eudragit RS 100 as rate controlling polymer in three different ratios like 1:1, 1:1.5 and 1:2 to achieve desired release in later case. Evaluation was performed according to the Pharmacopoeia standards including Drug excipients compatibility, Percentage yield, Particle size distribution, Drug content analysis and in-vitro release study. The best results were found to be using Almotriptan and Eudragit RS 100 in 1:2 ratios. A broad variety of drug release pattern could be achieved by variation of polymers ratios which was optimized to match the target release profile. In comparison of in-vitro release studies for different controlled release formulations, F9 releases 98.54% of drug at the end of 12th hour and was considered as best formulation. Stability study has shown no significant change in the drug content analysis and in-vitro dissolution study of best formulation even after 6 months.


Keywords: Almotriptan, Controlled release, Dissolution profile, in-vitro drug release, Stability studies.

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Author Biographies

Yerikala Ramesh, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

Abhilash Kaki Rohan, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

Balasaradhi Koorapati, Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

Department of Pharmaceutics, Ratnam Institute of Pharmacy, Pidathapolur (V & P), Muthukur (M), SPSR Nellore (Dt) - 524346, Andhra Pradesh, India.

P. Sudarsanam, Department of Pharmaceutics, Seshachala College of Pharmacy, Nagari Road, Puttur – 517583, Chittoor (Dist), Andhra Pradesh, India.

Department of Pharmaceutics, Seshachala College of Pharmacy, Nagari Road, Puttur – 517583, Chittoor (Dist), Andhra Pradesh, India.

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How to Cite
Ramesh, Y., Kaki Rohan, A., Koorapati, B., & Sudarsanam, P. (2019). Formulation and evaluation of almotriptan controlled release pellets. Journal of Drug Delivery and Therapeutics, 9(1-s), 312-318. https://doi.org/10.22270/jddt.v9i1-s.2355

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