Comparative study on prophylactic antibiotic versus empirical antibiotic in prevention of surgical site infection

  • S Rajarajan Professor, Department of pharmacy practice, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India
  • T.H. Sreelekshmi Devi Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India
  • Neeshma Mariam Simon Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India
  • K.R. Navin Shankar Government headquarters District Hospital, Tirpur, Tamil Nadu, India
  • V. Ganesan Department of Pharmaceutics, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India.

Abstract

The main aim of the study was to comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotics in prevention of surgical site infection. The study was a prospective observational study conducted over a period of 8months. A total of 100 number of surgery cases were selected randomly, to groups of 50 each. The study group received a single dose of antibiotic preoperatively while the control group received 3 to 5 days of empirical antibiotic therapy. Data analysis and statistical analysis was done with the help of graph pad prism trial version software. Student t test was carried out for paired analysis to find P value. There was no significant association of surgical site infection, grades of infection, and other complications. The hospital stay of patients, cost to the patients, and number of antibiotics used in patients were significantly more. The single dose prophylactic antibiotics are better than empirical post operative therapy in reducing the hospital stay and hospital cost to patients. Since the complete eradication of surgical site infection is not possible, only the reduction in infection rate can be achieved to a minimal level.


Keywords: Prophylactic antibiotics, surgical site infection, surgical complications, post operative antibiotics.

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Author Biographies

S Rajarajan, Professor, Department of pharmacy practice, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India

Professor, Department of pharmacy practice, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India

T.H. Sreelekshmi Devi, Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India

Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India

Neeshma Mariam Simon, Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India

Pharm D, The Erode College Of Pharmacy And Research Institute Erode, Tamil Nadu, India

K.R. Navin Shankar, Government headquarters District Hospital, Tirpur, Tamil Nadu, India

Government headquarters District Hospital, Tirpur, Tamil Nadu, India

V. Ganesan, Department of Pharmaceutics, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India.

Department of Pharmaceutics, The Erode College Of Pharmacy And Research Institute, Erode, Tamil Nadu, India.

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1.
Rajarajan S, Sreelekshmi Devi T, Simon NM, Navin Shankar K, Ganesan V. Comparative study on prophylactic antibiotic versus empirical antibiotic in prevention of surgical site infection. JDDT [Internet]. 15Mar.2019 [cited 18Jan.2021];9(2):9-3. Available from: http://jddtonline.info/index.php/jddt/article/view/2344