A Review on anti-epileptic activity of seaweed Ecklonia cava

  • Samiat Abimbola Owoalade Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.
  • Diana Moria Martin Lou Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.
  • Kashikant Yadav Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.
  • Sumitra Poudel Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Abstract

The Present study was undertaken to investigate the Anticonvulsant activity of sea weed extract of Ecklonia cava on electrically and chemically induced seizures in wistar rat. The methanolic seaweed extract was studied for its anticonvulsant activity by using experimental paradigms like Maximal electroshock-induced seizures (MES). Expected to exhibited protection against tonic convulsions induced by MES in wistar rats. Objective of these studies were designed to screen the antiepileptic activity of the seaweed Ecklonia cava in experimental laboratory animals.


Keywords: Antiepileptic Activity, Ecklonia cava (E.C), seizures, Flexon, Hind Limb Extension, Electroencephalography (EEG)

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Author Biographies

Samiat Abimbola Owoalade, Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Diana Moria Martin Lou, Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Kashikant Yadav, Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Sumitra Poudel, Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

Karnataka college of pharmacy, Campus # 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Bangalore North, Bengaluru, Karnataka 560064, India.

References

1) Saraceno B, Avanzini G, Lee P, eds. Atlas:Epilepsy Care in the World, World Health Organization .2005.
2) Eadie MJ, Bladin PF, A Disease Once Sacred: A History of the Medical Understanding of Epilepsy. John Libbey, Eurotext. 2001.
3) “Epilepsy: An historical overview” World Health Organization. on Feb 2001.
4) “Epilepsy: An historical overview” World Health Organization. on 20 January 2011.
5) Magiorkinis E, Sidiropoulou K, Diamantis A, "Hallmarks in the history of epilepsy: epilepsy in antiquity", Epilepsy & Behavior, 2011; 17(1):103–8.
6) World Health organisation, February 2016.Archived from the original on 11 March 2016.
7) Temkin O,The Falling Sickness:A History of Epilepsy from the Greeks to the Beginnings of Modern Neurology, JHU Press. p. Section 1.
8) Stol M, Epilepsy in Babylonia, BRILL 1993, page 143.
9) Harding GF, Jeavons PM, Photosensitive Epilepsy, the Cambridge University Press. 1994 page 2.
10) Jilek-Aall L, "Morbus sacer in Africa: some religious aspects of epilepsy in traditional cultures". Epilepsia., 1999; 40(3):382–6
11) Illes J,Harper C, Enclyclopedia of Mystics, Saints and Sages,. 2011 p.age 1238.
12) Perucca P, Gilliam FG, "Adverse effects of antiepileptic drugs". The Lancet. Neurology. 2012; (9):792–802.
13) Caravati EM .Medical toxicology (3rd ed.). Philadelphia [u.a.]: Lippincott Williams & Wilkins. Page 789.
14) K. Usha Rani, P. Venkateswara Rao et.al. Evaluation of anticonvulsant activity of aqueous root extract of Cocos Nucifera linn In mice, International Journal of Research in Pharmacy and Pharmaceutical Sciences. Nov 2016; 1(5):23-26.
15) Chaudhary Bhawana, Suthar Sushil and Sharma Amit, Evaluation of antiepileptic activity of Datura metal leaf extract in experimental animal, international journal of research in pharmacy and chemistry. 2016; 6(3):451-57.
16) A.D. Chimbalkar et al. Antiepileptic Activity of Ethanolic and Petroleum Ether Extracts of Leucas cephalotes (Roxb.) in Isoniazid and Strychnine Induced Convulsions. Ijppr.Human. April 2016; 6(1):393-02.
17) Jerome EJ, Pedley A, Timothy ED. Introduction: what is Epilepsy, chapter 1 in Epilepsy: A Comprehensive Textbook, Lipppincott- Raven Publshers .Philadelphia, 1997; 1-7.
18) Benbadis SR. Epileptic Seizures and Syndromes. Neurologic clinics. 2001; 19(2):251-70.
19) Sharma K. Genetic Epidemiology Of Epilepsy; A twin study, Neurol India .2005; 53(1):93- 98.
20) Fisher R, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)".Epilepsia. 2005; 46(4):470-72.
21) Herman ST. Single Unprovoked Seizures. Curr Treat Options Neurol. 2004; 6(3):243-55.
22) Anitha Jebamalai Raj, Sudarsanam Dorairaj, Velliyur Kanniappan Gopalakrishnan, et.al Phytomedicine: Indian medicinal plants as a source of anticonvulsant. Dec 2011; 11(2):94-99.
23) Lisa Francesca Andermann. Epilepsy in our World: An Ethnographic View. Epilepsy Behav. 2000; 1(3):169-75.
24) Mattson RH. Drug treatment of partial epilepsy. Adv neural. 1992; 57:643-50.
25) Sharma K. Genetic Epidemiology Of Epilepsy; A twin study, Neurol India .2005; 53(1); 93- 98.
26) Fisher R, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)".Epilepsia. 2005; 46(4):470-72.
27) Herman ST. Single Unprovoked Seizures. Curr Treat Options Neurol. 2004; 6(3):243-55.
28) Anitha Jebamalai Raj, Sudarsanam Dorairaj, Velliyur Kanniappan Gopalakrishnan, et.al Phytomedicine: Indian medicinal plants as a source of anticonvulsant. Dec 2011; 11(2):94-99.
29) Lisa Francesca Andermann. Epilepsy in our World: An Ethnographic View. Epilepsy Behav. 2000; 1(3):169-75.
30) Mattson RH. Drug treatment of partial epilepsy. Adv neural. 1992; 57:643-50 .
31) Lowenstein DH. Seizure and epilepsy. In: Braunwald E, Fauci AS, Hauser SL, eds. Harrison’s Principles of Internal Medicine. 15th ed. New York: McGraw-Hill; 2001:2354-69.
32) Kalabharathi HL, Sushma V, Pushpa VH, Satish AM. Anticonvulsant activity of calcium channel blockers on experimentally induced seizures in animal models. Int J PharmSci. 2014; 6(1):541-46.
33) Roopa B., Janardhan M., Venkata Rao Y, Evaluation of anticonvulsant activity of amlodipine in albino rats, Int J Basic Clin Pharmacol. 2017; 6(3):664-68
34) Moron M.A, Stevens C.S, Yakash T.L. The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. Jr. Pharmacol. Exp.Ther.1990; 252:1150.
35) Schwartzkroin P A, Wylar A.R. Mechanisms underlying epileptiform burst discharge. Ann. Neurol. 1980; 7:95-107.
36) Kamal J A. Effect of calcium channel blockers on experimentally induced seizures in rats. Ind. Jr.Exp. Biol.1990; 28:608-10.
37) Sunil Joseph, Joy david, Thangam Joseph. Synergistic effect of flunarizine and sodium valproate on seizure thresholds elicited by cortical stimulation in conscious rats. Ind. Jr.Physiol. Pharmacol.1998; 42(3):383.
38) Kishore M.S, Pushpa V.H, Padmaja Shetty, Kalabharathi H.L, Satish A.M, Evaluation of the antiepileptic activity of felodipine in albino mice, Int J Pharm Pharm Sci 6:(6)498-500.
39) Anonymous. Executive Summary. In Atlas: Epilepsy Care in the world. Geneva : World Health Organization, 2005; 3.
40) Prashamsa Koirala, Hyun Ah Jung, Jae Sue Choi, Recent advances in pharmacological research on Ecklonia species. Arch. Pharm. Res. 2017; 40:981–1005.
41) Kenneth L, Huyen T.P and Long D.D, Interaction of Plant Extracts with Central Nervous System Receptors, Medicines 2017; (4)12.
42) Cho, S.; Han, D.; Kim, S.B.; Yoon, M.; Yang, H.; Jin, Y.H.; Jo, J.; Yong, H.; Lee, S.H.; Jeon, et al. Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed. Biosci. Biotechnol. Biochem. 2012 (76) 163–168.
43) Young-Dae K , Jung-Pyo, Hong-In Song ,Mi Seon ,Tae S.M ,Hyun Il Yoo, Studies on technology for seaweed forest construction and transplanted Ecklonia cava growth for an artificial seaweed reef, J. Environ. Biol.2012; (33):969-975.
44) bladelet of Ecklonia cava Kjellman (Laminariales, Phaeophyta) in two localities with different temperature conditions. Phycol. Res, 2001; (49):1-11.
45) Serisawa, Y., Z. Imoto, T. Ishikawa and M. Ohno: Decline of the Ecklonia cava population associated with increased seawater temperatures in Tosa Bay, southern Japan. Fisheries Sci, 2004; (70):189–191 .
46) Tominaga, H., Y. Serisawa and M. Serisawa Y., Y. Yokohama, Y. Aruga and J. Tanaka: Photosynthesis and respiration in Ohno: Morphology, density and biomass of Ecklonia cava Kjellman growing in different depths off the Tei coast in Tosa Bay, Japan. Bull. Mar. Sci. Fish. Kochi. Univ, 1999; (19):63–70.
47) Jeong-won Lee, Jin Kyung Seok, and Yong Chool Boo, Ecklonia cava Extract and Dieckol Attenuate Cellular Lipid Peroxidation in Keratinocytes Exposed to PM10, Evidence Based Complementary and Alternative Medicine, 2018; (1):1-12.
48) Maegawa, M., Yokohoma, Y., and Aruga, Y. (1987) Critical light conditions for young Ecklonia cava and Eisenia bicyclis with reference to photosynthesis. Hydrobiologia 1987; (151):447–455.
49) Heo SJ, Park E.U, Lee K.W, and Jeon Y.J, Antioxidant activity of enzymatic extract from brown seaweed, Biores.Technol,2005;(96);1613-23.
50) Kang K. A, Lee K. H, Chae .S, Zhang .R, Jung M.S, Lee.Y, Kim S.Y., Kim H. S., Joo H. G, et. al,Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damaged in lungs fibroblast cells, FEBBS lett, 2005; (579);6295-6304.
51) Isuru Wijesekara, Na Yong Yoon, S.J Kim, Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits, research gate, 2010; (6);408-14 .
52) Moon C, Kim SH, Kim JC, Hyun JW, Lee NH, Park JW, Shin T, Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice. Phytother Res 2008; (22);238–242.
53) Kang K, Hwang HJ, Hong DH, Park Y, Kim SH, Lee BH, Shin HC, Antioxidant and anti-inflammatory activities of ventol, a phlorotannin-rich natural agent derived from Ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture. Res Commun Mol Pathol Pharmacol 2003; (115);77–95.
54) Kumar CS, Ganesan P, Suresh PV, Bhaskar N, Seaweeds as a source of nutritionally beneficial compounds—a review. J Food Sci Technol, 2008; (45):1–13.
55) Heo SJ, Park PJ, Park EJ, Cho SK, Kim SK, Jeon YJ, Antioxidative effect of proteolytic hydrolysates from Ecklonia cava on radical scavenging using ESR and H2O2-induced DNA damage. Food Sci Biotechnol 2005; (14);614–620.
56) Kim AR, Lee B, Joung EJ, Gwon WG, Utsuki T, Kim NG, Kim HR, 6,’6-Bieckol suppresses inflammatory responses by down regulating nuclear factor-kB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells. Immunopharmacol Immunotoxicol, 2016;(38):244–252.
57) Choi JS, Bae HJ, Kim SJ, Choi IS, In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes. J Environ Biol 2011; (32);313–318.
58) Jung HA, Yoon NY, Woo MH, Choi JS , Inhibitory activities of extracts from several kinds of seaweeds and phlorotannins from the brown alga Ecklonia stolonifera on glucose-mediated protein damage and rat lens aldose reductase, Fish Sci 2008; (74);1363–1365.
59) Kong CS, Kim JA, Yoon NY, Kim SK, Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells. Food Chem Toxicol,2009; (47);1653–1658 .
60) Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK,The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol Pharm Bull 2006;(29);1735–1739
61) Artan M, Li Y, Karadeniz F, Lee SH, Kim MM, Kim SK, AntiHIV-1 activity of phloroglucinol derivative, 6’6--bieckol, from Ecklonia cava. Bioorg Med Chem 2008; (16):7921–7926 .
62) Jung HA, Hyun SK, Kim HR, Choi JS, Angiotensin-converting enzyme I inhibitory activity of phlorotannins from Ecklonia stolonifera. Fish Sci , 2006; (72);1292–1299 .
63) Jung HA, Kim JI, Choung SY, Choi JS, Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol 2014; (66);1180–1188 .
64) Le QT, Li Y, Qian ZJ, Kim MM, Kim SK, Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release. Process Biochem 2009; (44);168–176 .
65) Kang HS, Chung HY, Kim JY, Son BW, Jung HA, Choi JS,Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation. Arch Pharm Res 2004; (27);194–98.
66) Kim KC, Lee IK, Kang KA, Piao MJ, Ryu MJ, Kim JM, Lee NH, Hyun JW (2014a) Triphlorethol-A from Ecklonia cava upregulates the oxidant sensitive 8-Oxoguanine dna glycosylase 1. Mar Drugs 2014; (12);5357–71.
67) Kim AD, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW Cytoprotective effect of Eckol against oxidative stress-induced mitochondrial dysfunction: involvement of the FoxO3a/AMPK pathway. J Cell Biochem. 2014; (115);1403–11 .
68) Kim EA, Lee SH, Ko CI, Cha SH, Kang MC, Kang SM, Ko SC, Lee WW, Ko JY, Lee JH, Kang N Protective effect of fucoidan against AAPH-induced oxidative stress in zebrafish model. Carbohydr Polym 2014; (102);185–91.
69) Kim EA, Kang MC, Lee JH, Kang N, Lee W, Oh JY, Jeon YJ Protective effect of marine brown algal polyphenols against oxidative stressed zebrafish with high glucose. RSC Adv 2015; (25);738–46 .
70) Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties. J Agric Food Chem 2009; (57):3483–89.
71) Rall TW, Schleifer LS. Drugs effective in the therapy of the epilepsies. In: Gilman AG, Rall TW, Nies AS, Taylor P, Editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. New York: Pergamon Press, 1991; (8):436–8.
72) Porter RJ, Meldrum BS. Antiepileptic drug. In: Katzung BG, Editor. Basic and Clinical Pharmacology, London: Prentice Hall Inc. Ltd. 1995; (6):361-3.
73) Suresh Kumar, Reecha Madaan, Gundeep Bansal, Anupam Jamwal, Anupam Sharma, Plants and Plant Products with Potential Anticonvulsant Activity, Pharmacognosy Communications, Volume 2 | Issue 1 (Suppl.) | Jan-Mar 2012.
74) Gupta YK, Malhotra J, George B, Kulkarni SK. Methods and consideration for experimental evaluation of antiepileptic drugs. Indian J Physiol Pharmacol. 1999; 43(1):25–43.
75) Basavraj P, Shivkumar B, Shivkumar H, Manunath, nanjappaih H M,Evaluation of anticonvulsant activity of semecarpus anacardium (linn)nut extract int journal of pharmaceutical sciences and research.2011; 2(6):1572-81.
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How to Cite
Owoalade, S., Martin Lou, D. M., Yadav, K., & Poudel, S. (2019). A Review on anti-epileptic activity of seaweed Ecklonia cava. Journal of Drug Delivery and Therapeutics, 9(1-s), 425-432. https://doi.org/10.22270/jddt.v9i1-s.2335