Formulation and evaluation of matrix transdermal patches of meloxicam

  • Sumit Chourasia School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India
  • Tripti Shukla School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India
  • Surendra Dangi School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India
  • Neeraj Upmanyu School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India
  • Nidhi Jain School of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Village-pachama, Sehore, M.P.-466001, india

Abstract

The present study deals with the formulation and evaluation of transdermalpatches of meloxicam towards enhance its permeation through the skin and maintain the plasma levelconcentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and isopropylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Amongthe formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observedfor the formulations F12 and F4i.e. 80.012 ± 2.012 % and 98.365±3.012%. The mechanism of drugrelease was found to be Non-Fickian diffusion controlled. FT-IR studies revealed theintegrity of the drug in theformulations.


Keywords: Transdermal Patches, Meloxicam, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.

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Author Biographies

Sumit Chourasia, School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

Tripti Shukla, School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

Surendra Dangi, School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

Neeraj Upmanyu, School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

School of Pharmacy, People's University, Ayodhya Bypass Rd, Peoples Campus, Bhanpur, Bhopal, Madhya Pradesh- 462037, India

Nidhi Jain, School of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Village-pachama, Sehore, M.P.-466001, india

School of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Village-pachama, Sehore, M.P.-466001, india

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How to Cite
Chourasia, S., Shukla, T., Dangi, S., Upmanyu, N., & Jain, N. (2019). Formulation and evaluation of matrix transdermal patches of meloxicam. Journal of Drug Delivery and Therapeutics, 9(1-s), 209-213. https://doi.org/10.22270/jddt.v9i1-s.2326