Synthesis of some Glyco-amino acid congeners
Macromolecules have been widely useful for drug delivery purpose. The fusion of drug with macromolecule could offer controlled or time specific drug delivery. Glyco amino acids are a carbohydrate derivative which occurs in nature as a subunit of oligosaccharides in cell walls of bacteria and in some antibiotic. Glyco-peptide presents an exclusive research in glycobiology for drug discovery, drug delivery and other biotechnological application. This work was on the synthesis and characterization of glyco amino acids based on monosaccharide (D-glucosamine) and amino acids as reactant. The synthesized compound was characterised by physicochemical properties and their spectral analysis. These glycosylated amino acid building blocks can be utilized in the synthesis of glycopeptides, generation of glycomimetic libraries, Preparation of glycoconjugates, glycotargetting, and inhibition of carbohydrate-protein binding.
Keywords: glycopeptides, glycomimetics, glycotargetting, glycoconjugate
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