Acute and sub-acute toxicity studies of flower extract of Tridex procumbens in albino rats
Aim- The study was designed to evaluate the Acute & Sub-acute Toxicity Studies of Flower Extract of Tridex procumbens. Material & Methods-Dried powder of flower part was extracted by using chloroform: methanol solvent by using soxhlet apparatus for 72 hrs. Preliminary phytochemical screening was performed for the presence of various phytoconstituents. The chloroform: methanol extract was evaluated by using the acute and sub-acute toxicity studies. The acute toxicity study was also evaluated by administration of extract after oral and intraperitoneal extract. Various parameters i.e. body weight, clinical signs, hematological parameters and clinical chemistry parameters were evaluated. Result- In acute toxicity studies, there were no side effects at the dose of 2000 mg/kg. The sub-acute toxicity was performed at 100, 300 and 1000 mg/kg. There were some changes in body weight, organ weights, hematological parameters and clinical chemistry parameters. However, no toxic effects were seen at his dose. Conclusion- The results showed that no death of experimental rats at an oral dose of 2000 mg/kg body weight symptomatic of that the chloroform: methanol extract of Tridex procumbens flower is virtually non-toxic after oral dose exposure presuming that its components were engrossed. The extract can then be concluded to be safe for oral use as a traditional herbal remedy for the different ailments.
Keywords: Flower extract, acute toxicity, sub-acute study, chloroform: methanol extract, Tridex procumbens
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).