A REVIEW ON FAST DISSOLVING TABLETAntidiabetic and anticataract evaluation of different extracts of Butea monosperma Linn. in STZ induced diabetic animals
Abstract
Aim- The main aim of study is to evaluate the anti-diabetic and anti-cataract activity of different extracts of Butea monosperma in diabetic animals. Material & Methods- Different extracts were prepared by successive solvent extraction methods. All the extracts were examined for the presence of different phytoconstituents. Diabetes was induced by single injection of STZ (40mg/kg) in Wistar albino rats and diabetes was confirmed by measurement of blood glucose level with the help of glucometer which is based on glucose oxidation methods. For the anti-cataract activity cataract was induced by solution of glucose in goat lenses and different biochemical parameters i.e. MDA, Na+, K+ were measured. Results- Preliminary phytochemical screening methods showed the presence of alkaloids, flavonoids, terpenoids, glycosides etc. In anti-diabetic evaluation, butanolic extract showed a highly significant activity in diabetic animals as compared to other extracts. So butanolic extract was further selected for the anti-cataract activity in goat eye lenses. Butanolic extract also highly significantly affect cataract formation all related biochemical parameters and electrolyte level. Conclusion- Administrations of butanolic extract have significant antidiabetic effect in STZ induced diabetes. Butanolic extract exhibited potent anti-hyperglycemic, antioxidant and anti-cataract effects in STZ induced type 2 diabetic rats. This effect may be presence of flavonoids in butanolic extract.
Keywords: Cataract, STZ induced diabetes, Butea monosperma, Butanolic extract, Hyperglycemia
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.