Design, Development, Characterization and in-vitro Evaluation of Medicated Chewing Gum: Granisetron Hydrochloride
AbstractMedicated Chewing Gums are mobile drug delivery systems. It is a potentially useful means of administering drugs either locally or systemically via, the oral absorption. The medicated chewing gum has through the years gained increasing acceptance as a drug delivery system. e.g. Aspirin as an analgesic, Chlorhexidine as local disinfectant, Fluoride for prophylaxis of dental caries, Nicotine for smoking cessation, Caffeine as a stay alert preparation and Dimenhydrinate as antiemetic drugs etc. MCGs are solid, single dose preparations with a base consisting mainly of gums that are intended to be chewed but not swallowed. They contain one or more active substances which are released by chewing and are intended to be used for local treatment of mouth diseases or systemic delivery after absorption through the buccal mucosa and improve the oral bioavailability of drugs undergoing first pass metabolism.
Keywords: Chewing gums, Mobile Drug Delivery System, Dental Caries, Emesis, Local Disinfectant, Mouth Diseases
Download data is not yet available.
33 Views | 48 Downloads
How to Cite
Agrawal, A., & Sudhakar, C. (2019). Design, Development, Characterization and in-vitro Evaluation of Medicated Chewing Gum: Granisetron Hydrochloride. Journal of Drug Delivery and Therapeutics, 8(6-A), 43-47. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2315
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).