Synthesis and Characterization of 1, 3, 4-Oxadiazole Derivatives

  • Anuj Singhai Research Scholar, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India
  • M.K. Gupta Professor and Dean, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India

Abstract

1,3,4-oxadiazole is a five member heterocyclic ring which is a very important compound for designing potent bioactive agents. This interesting group of compound has different biological activities such as anti-inflammatory, antimicrobial, anticancer, antitubercular, anticonvulsant, anti-HIV, hypogycemic and antioxidant etc. In the present research work, we have synthesized four newly 1,3,4-oxadiazole derive atives derived from existing NSAID Ibuprofen. The purity of compounds was checked by TLC and melting point. The melting point was determined by open capillary methods and uncorrected. Structure of all four newly synthesized compounds was confirmed by spectral analysis (FTIR, and 1HNMR).


Keywords: Oxadiazole, 1, 3, 4-Oxadiazole derivatives, Heterocyclic, Ibuprofen, Cyclic compound.

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Author Biographies

Anuj Singhai, Research Scholar, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India

Research Scholar, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India

M.K. Gupta, Professor and Dean, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India

Professor and Dean, Oriental College of Pharmacy and Research, Oriental University, Indore (MP), India

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How to Cite
Singhai, A., & Gupta, M. (2019). Synthesis and Characterization of 1, 3, 4-Oxadiazole Derivatives. Journal of Drug Delivery and Therapeutics, 8(6-A), 25-27. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2312