Evaluation of lens aldose reductase inhibitory potential of fruit extracts of Terminalia bellerica Roxb.

  • Kushagra Dubey Smriti College of Pharmaceutical Education, Indore (M.P.), India
  • Raghvendra Dubey Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india
  • Revathi A Gupta Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india
  • Arun Gupta

Abstract

Aim: The aim of the research work was to carried out the antidiabitic inhibitory potential of the fruit extracts of T. Bellerica Roxb. against Aldose Reductase enzyme.


Material & Methods: The dried fruit powder of T. Bellerica Roxb was extracted by successive solvent extraction method to obtained methanolic  and aqueous extract. Both the extracts were screened for invitro aldose reductase inhibitory activity in purified goat lens using Hayman and Kinoshita method in which decrease in NADPH concentration was estimated at 340nm using UV Visible spectrophotometer.


Result & Discussion:  From the result it was observed that both the extracts inhibit AR activity, but at different extent. From dose response curve it was found that methanolic extract (ME) is more effective then aqueous extract (AE) with IC50 values of 25.26 ±0.23 µg/ml and 109.14 ±1.15 µg/ml respectively.  


Conclusion:  In the end it was concluded that among the two extracts, methanolic extract of T. Bellerica Roxb is potent in inhibiting the aldose reductase enzyme which contribute major role in the diabetes complication.


Keywords: Aldose Reductase, Goat Eye Lens, NADPH,  Methanolic Extract, Aqueous extract.

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Author Biographies

Kushagra Dubey, Smriti College of Pharmaceutical Education, Indore (M.P.), India

Smriti College of Pharmaceutical Education, Indore (M.P.), India

Raghvendra Dubey, Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india

Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india

Revathi A Gupta, Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india

Faculty of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), india

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How to Cite
Dubey, K., Dubey, R., Gupta, R. A., & Gupta, A. (2019). Evaluation of lens aldose reductase inhibitory potential of fruit extracts of Terminalia bellerica Roxb. Journal of Drug Delivery and Therapeutics, 8(6-A), 16-18. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2310