Ulva reticulata, a marine alga normalize streptozotocin induced lipid peroxidation in experimental diabetic rats

  • N. Ashok Kumar Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.
  • T. Sharunetha Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.

Abstract

Increased oxidative stress is directly involved in the development and progression of diabetes which leads to impairment of antioxidant status and increased free radical production.  The present study was aimed to evaluate the effects of ethanolic extract of marine algae Ulva reticulata on plasma glucose, insulin, TBARS, lipid hydroperoxides and non enzymatic antioxidants including vitamin E, vitamin C and reduced glutathione (GSH) in streptozotocin (STZ) induced diabetic rats.    Diabetes was induced by single intraperitoneal injection of STZ at a dose of 45 mg/kg body weight. Male wistar rats were randomly divided in to four groups. Diabetic rats treated with oral administration of ethanolic extract of   U. reticulata for 45 days resulted in a significant reduction in fasting plasma glucose, TBARS, lipid hydroperoxides  and elevated the activities of plasma insulin, vitamin E, vitamin C and reduced glutathione (GSH)   when comparison with diabetic control group. Seaweeds are a valuable food resource which contains low calories, and are rich in vitamins, minerals, proteins, polysaccharides, steroids and dietary fibers. These findings suggest that U. reticulata extract have potent protective effect on STZ induced lipid peroxidative changes in diabetic rats.


Keywords: Ulva reticulata, Diabetes, STZ, Oxidative stress, Antioxidant

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Author Biographies

N. Ashok Kumar, Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.

T. Sharunetha, Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.

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Ashok Kumar, N., & Sharunetha, T. (2019). Ulva reticulata, a marine alga normalize streptozotocin induced lipid peroxidation in experimental diabetic rats. Journal of Drug Delivery and Therapeutics, 8(6-A), 12-15. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2309