A systematic review on hepatocellular carcinoma: diagnosis and therapies for patients

  • Avinash Shankar Bhosale Department of Pharmacy, Oriental University, Indore, Madhya Pradesh, India,
  • Mahesh Babanrao Thorat
  • Bhushan Raghunath Pawar
  • Gurdeep Singh
  • M. K. Gupta


Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. Hepatocellular carcinoma (HCC) represents one of the most challenging potentially curable tumors with high incidence, prevalence and mortality rates.  HCC is the fifth most common cancer and the third cause of cancer-related mortality worldwide. Its incidence is clearly arising comprised by the prevalence of major risk factors mainly hepatitis B and hepatitis C. The population at risk is composed of chronic liver patients at the stage of extensive fibrosis or cirrhosis. The monitoring programs of this population have allowed early detection of disease management to promote a radical therapy. Understanding the carcinogenic process and the mastery of the staging systems remain essential keys in diagnosis and treatment of HCC. Recent advances in diagnosis and new treatments have made important impacts on the disease by increasing survival rates and improving quality of life for HCC patients.

Keywords: Hepatocellular carcinoma (HCC), hepatitis B and hepatitis C, radical therapy, new treatments.


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Author Biography

Avinash Shankar Bhosale, Department of Pharmacy, Oriental University, Indore, Madhya Pradesh, India,

Department of Pharmacy, Oriental University, Indore, Madhya Pradesh, India,


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Bhosale AS, Thorat MB, Pawar BR, Singh G, Gupta MK. A systematic review on hepatocellular carcinoma: diagnosis and therapies for patients. JDDT [Internet]. 10Jan.2019 [cited 2Jul.2020];8(6-A):116-23. Available from: http://jddtonline.info/index.php/jddt/article/view/2299