Formulation of fast dissolving ketoprofen tablet by solid dispersion technique

  • Rahul Sisodiya Oriental College of Pharmacy and Research, Oriental University, Indore Madhya Pradesh

Abstract

Recent developments in fast dissolving/disintegrating tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The objective of the present study was to prepare the mouth disintegrating tablet of ketoprofen (NSAID). As precision of dosing and patient's compliance become important prerequisite for a long term NSAID treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient's acceptability. Hence, the present investigation was undertaken with a view to develop a fast disintegrating tablet of ketoprofen which offers a new range of product having desired characteristics and intended benefits. The drug is poorly water soluble therefore to enhance the solubility and release of drug, solid dispersion of drug with mannitol was prepared by melt solvent method and melting method. In addition, the physical mixture was prepared for comparison. Different superdisintegrants such as croscarmellose sodium, sodium starch glycolate, crospovidone were used. Directly compressible mannitol was used as a carrier and to enhance the mouth feel and taste. The tablets were prepared by direct compression technique on rotary tablet machine. The tablets were evaluated for hardness, friability, weight variation, wetting time, dispersion time and uniformity of content and in vitro dissolution test. All the tablets had hardness 3-4.5 kg/cm2 and friability of all formulations was less than 1%, weight variation and drug content were within official limit.


Keywords: Ketoprofen; FDT; Superdisintegration; NSAIDS; Direct Compressible Mannitol

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Author Biography

Rahul Sisodiya, Oriental College of Pharmacy and Research, Oriental University, Indore Madhya Pradesh

Oriental College of Pharmacy and Research, Oriental University, Indore Madhya Pradesh

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How to Cite
Sisodiya, R. (2019). Formulation of fast dissolving ketoprofen tablet by solid dispersion technique. Journal of Drug Delivery and Therapeutics, 8(6-A), 85-92. Retrieved from http://jddtonline.info/index.php/jddt/article/view/2294