Formulation and evaluation of sustain released matrix tablet of atenolol

  • Sonal Sahu NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Rohit Dangi NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Rohit Patidar NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • , Rukhsaar NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Jagdish Rathi NRI Institute of Pharmaceutical Sciences, Bhopal, India
  • Vivek Asati NRI Institute of Pharmacy

Abstract

Oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form. The aim of present investigation was to develop matrix tablets of atenolol using different polymers. Atenolol matrix tablets were prepared by direct compression and wet granulation method using different polymers. All the formulations were evaluated for weight variation, thickness, hardness, friability and dissolution. Tablets of atenolol were prepared utilizing natural polymer chitosan. The formulation F-2 contained chitosan which might have sustained the release since it is also known for its polymeric sustaining effect. The formulation F-2 gave 89.57±0.24% of the drug release in 12 hrs of study.


Keywords: Atenolol, Sustained release Matrix tablets, Direct compression, Wet granulation method.

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Author Biographies

Sonal Sahu, NRI Institute of Pharmaceutical Sciences, Bhopal, India

NRI Institute of Pharmaceutical Sciences, Bhopal, India

Rohit Dangi, NRI Institute of Pharmaceutical Sciences, Bhopal, India

NRI Institute of Pharmaceutical Sciences, Bhopal, India

Rohit Patidar, NRI Institute of Pharmaceutical Sciences, Bhopal, India

NRI Institute of Pharmaceutical Sciences, Bhopal, India

, Rukhsaar, NRI Institute of Pharmaceutical Sciences, Bhopal, India

NRI Institute of Pharmaceutical Sciences, Bhopal, India

Jagdish Rathi, NRI Institute of Pharmaceutical Sciences, Bhopal, India

NRI Institute of Pharmaceutical Sciences, Bhopal, India

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How to Cite
Sahu, S., Dangi, R., Patidar, R., Rukhsaar, , Rathi, J., & Asati, V. (2019). Formulation and evaluation of sustain released matrix tablet of atenolol. Journal of Drug Delivery and Therapeutics, 9(1), 183-189. https://doi.org/10.22270/jddt.v9i1.2281