Design Development and Evaluation of Agomelatine Microemulsion for Intranasal Delivery
The purpose of this study was to develop and optimize microemulsion containing agomelatine for intranasal delivery. Agomelatine, an antidepressant drug, has absolute bioavailability of only 5% due to high first pass metabolism. Agomelatine microemulsion and were prepared by titration method. Ternary phase diagram gave the microemulsion region and the concentration of oil; Smix and water were selected from ternary phase diagram. Based on solubility study, oleic acid, tween 80 and propylene glycol were selected as oil, surfactant and co surfactant respectively. Microemulsions were prepared using water titration method. 1:1% v/v ratio (Tween 80: Propylene glycol) was selected for formulation development. The prepared microemulsions were optimized optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies. The optimized batch was further characterized for optical transparency, viscosity measurement, phase separation, determination of pH, measurement of globule size, measurement of zeta potential, drug content, In vitro diffusion study, stability studies.
Keywords: Depression, Intranasal, Microemulsions, Agomelatine
2. Dhuria SV, Hanson LR, Frey IWH. Intranasal Delivery to The Central Nervous System: Mechanisms and Experimental Considerations. J of Pharm Sci 2010; 99(4):1654-1673.
3. Jaiswal PL, Darekar AB, Saudagar RB. A Recent Review on Nasal Microemulsion for Treatment of CNS Disorder. Inter J of Current Pharm Res 2017; 9(4):5-13.
4. Jaiswal PL, Darekar AB, Saudagar RB. A Recent Review on Nasal Microemulsion for Treatment of CNS Disorder. Inter J of Current Pharm Res 2017; 9(4):5-13.
5. Kakad JK, More PK, Gondkar SB, Saudagar RB. A Recent Review on Nasal Drug Delivery System. World J of Pharm Res 2015; 4(2):269-281.
6. Pagar SA, Shinkar DM, Saudagar RB. A Review on Intranasal Drug Delivery System. J of Adv Pharm Ed & Res 2013; 3(4):333- 346.
7. Mahajan HS, Rasal AD, Microemulsions for Nasal Drug Delivery Systems: An Overview. Inter J of Pharm Sci and Nanotech 2013; 5(4):1825- 1831.
8. Katiyar BS, Katiyar SS, Mishra PS and Sailaja DL, Microemulsions: A Novel Drug Carrier System. Inter J of Pharm Sci Review And Res 2013; 20(2):138- 148.
9. Muzaffar F, Singh UK, Chauhan L. Review on Microemulsion as Futuristic Drug Delivery. Inter J of Pharm and Pharm Sci 2013; 5(3):39- 53.
10. Madhav S, Gupta D. A Review on Microemulsion Based System. Inter J of Pharm Sci and Res 2011; 2(8):1888- 1899.
11. Vispute M, Sayyad N, Khan T, Shaikh S. An Overview on Exploring Nasal Microemulsion for Treatment of CNS Disorders. Inter J of Pharm Sci and Res 2013; 4(4):1294-1311.
12. Patadiya H, Agarwal J, Chaudhary S, Shah H. Microemulsion Based Nasal To Brain Delivery of Drug Acting on CNS. Inter J of Pharm Resand Bio-Sci 2015; 4(2):472-491.
13. Sinko PJ: Martin’s Physical Pharmacy and Pharmaceutical Sciences. 6th ed. Wolters Kluwer/ Lippincott wilkins; 2011.p. 17-53.
14. Thakkar HP, Patel AA, Chauhan NP. Formulation and Optimization of Mucoadhesive Microemulsion Containing Mirtazapine for Intranasal Delivery. Chronicles of Young Scientists 2014; 5(1):25- 32.
15. Darekar AB, Jaiswal PL, Saudagar RB. Design Development and Evaluation of Duloxetine Hydrochloride Microemulsion for Intranasal Delivery. Eur J of Biomedand Pharma Sci 2018; 5(2):679-684.
16. Bhise SB: Laboratery Manual of Biopharmacutics and Pharmacokinetics: Published by Trinity Publishing House; 2010. p. 64.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).