Chemical composition and antibacterial activity of essential oil of Senecio graciliflorus

  • B.C. Joshi Department of Chemistry, M.B.P.G. College, Haldwani, Nainital, Uttarakhand, India
  • Vinod Kumar Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India
  • Bhuwan Chandra Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India
  • N.D. Kandpal Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

Abstract

Objective: Among natural products, essential oils and their contituents represent a structurally diverse group of organic compounds with significant antibacterial activity. This  study  is  oriented  to  assess  the  therapeutic  potential  of  plant constituents as new antimicrobial drugs.


Methods: Aerial parts of Senecio graciliflorus was steam distilled and analysed by GC and GC-MS for the volatile constituents. Essential oil was studied for their antibacterial activity against Gram-positive and Gram-negative bacteria using agar well diffusion method.


Results: The results revealed that α-pinene and α-thujene are the major constituents of S. graciliflorus oil. In vitro studies showed significant antimicrobial activity against bacterial strains.


Conclusion: This study demonstrated that the oil significantly inhibits the growth of baceria. S. graciliflorus would be another alternative for developing new pharmaceuticals for prevention bacterial diseases and provide a direction for the study of naturally derived drugs.


Keywords: Asteraceae, Senecio graciliflorus, Essential oil, α-Pinene, Antibacterial activity.

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Author Biographies

B.C. Joshi, Department of Chemistry, M.B.P.G. College, Haldwani, Nainital, Uttarakhand, India

Department of Chemistry, M.B.P.G. College, Haldwani, Nainital, Uttarakhand, India

Vinod Kumar, Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

Bhuwan Chandra, Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

N.D. Kandpal, Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

Department of Chemistry, Kumaun University, S.S.J. Campus, Almora, Uttarakhand, India

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How to Cite
Joshi, B., Kumar, V., Chandra, B., & Kandpal, N. (2019). Chemical composition and antibacterial activity of essential oil of Senecio graciliflorus. Journal of Drug Delivery and Therapeutics, 9(1-s), 98-100. https://doi.org/10.22270/jddt.v9i1-s.2265