Formulation and in-vitro evaluation of theophylline sustained release tablet
The aim of present study was to prepare sustained release tablet of Theophylline so as to prolong its elimination time and at the same time to keep cost of the formulation minimum. In this study ethyl cellulose and Eudragit are used in the formulation to sustain the release of Theophylline. Ethyl cellulose and Eudragit are added at the granulation step to form a sustained release coating around each granule. Different batches were designed one after another on trial and error basis to get the optimum drug release upto 12 hours.
Keywords: Theophylline, ethyl cellulose, Eudragit, sustained release, coating, tablet.
2. Wise DL, Handbook of Pharmaceutical Controlled Release Technology, 2005; Marcel Dekker, INC., New York and Basel: 211, 435-440, 472-473, and 787-788.
3. Tetsuo B. and Kanbe S., Formulation study and drug release mechanism of new theophylline sustained release preparation, Int. J. Pharm. 2005; 304:91-101.
4. Yasim K. and Gokhan R., Different geometric shaped hydrogel theophylline tablets: Statistical approach for estimating drug release, Farmaco 2002; 57:939-945.
5. Lin F. and Wang H., Influence of plasticizers on the release of theophylline from micro porous-controlled tablets, J. Cont. Rel. 2004; 99:415-421.
6. Ali F. and Anish N., In situ cross-linking of sodium alginate with calcium and aluminium ions so as to sustain the release of theophylline from polymeric matrices, II Farmaco 2004; 59:999-1004.
7. Aulton ME. Pharmaceutics, The Science of Dosage form Design, 1998, 1st Edition. Churchill Livingstone.247-248, 603-606.
8. Martin’s Physical Pharmacy and Pharmaceutical sciences, 1991, 3rd Edn., Varghese Publishing House, Bombay, 512-516.
9. Shimona B. and Garic P., Bioadhesive grafted starch copolymers as platforms for peroral delivery: a study of theophylline release, J. Cont. Rel. 2004; 94:391-394.
10. Karasulu H. and Ertan C., Modeling of theophylline release from different geometrical erodible tablets, Eu. J. Pharm. & Biopharm. 2000; 49:177-182.
11. Gul R. and Jia N., Ibuprofen release kinetics from controlled-release tablets granulated with aqueous polymeric dispersion of ethyl cellulose II: influence of several parameters and coexcipients, J. Cont. Rel. 1998; 56:127-134.
12. Michael M. and Britta P., Physicochemical properties and mechanism of drug release and from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion, Int. J. Pharm. 2004; 269:509-522.
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