Formulation and evaluation of albendazole nanoparticle
Therefore, there is a need to develop alternative novel drug delivery formulations of albendazole to improve its intestinal absorption and also to reduce its side effects during regular therapy. The Albendazole nanoparticles were prepared by hot homogenization method under high magnetic stirring using stearic acid as lipid and poloxamer 188 was used as surfactant. Initial pre-formulation studies using FTIR spectroscopy reveals that there are no interactions between Albendazole and other excipients and hence they can be used for the preparation of nanoparticles. The entrapment efficiencies varied from a minimum of 43.56 ± 0.95 % to a maximum of 85.1 ±0.58% and it can be concluded that higher amount of lipid is necessary for obtaining a good entrapment efficiency. The drug content of albendazole nanoparticles for all formulation ranges from 65.8% to 98.1%. A spherical shape was observed for the particles and the particles had a smooth morphology when examined under SEM. In vitro release studies of the formulations carried out in pH 7.4 PBS showed that the total amount of drug is released for 9hrs with sustained effect. That the formulations showed a drastic increase in size when stored at room temperature where the size of particles increased from an initial to 343.7 ±7.9 nm at the end of 1 month to 898.1 ± 5.8 nm at the end of 2 months. Entrapment efficiency of the formulation was determined at each interval to ensure that the drug molecules didn’t undergo any degradation during storage.
Keywords: Albendazole, Nanoparticles, Particle size, Entrapment efficiency.
2. Wolfgang M, Karsten M. Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Del Rev 2001; 47:165-196.
3. Muller RH, Radtke M, Wissing SA, Solid lipid nanoparticles and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations, Adv. Drug Deliv. Rev. 2002; 54:131-155.
4. R.H. Muller, K. Mader, S. Gohla, Solid lipid nanoparticles for controlled drug delivery a review of the state of the art, Eur. J. Pharm. Bio harm. 2000; 50: 161– 177.
5. Cavalli R, Caputo O, Carlotti ME, Trotta M, Scarnecchia C, M.R. Gas co, Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles, Int. J. Pharm. 1997; 148:47-54.
6. Vijaya Suman Reddy D, Ramesh Y, Parameshwar K, Jhansi reddy K, Formulation and Evaluation of Mouth Dissolving Tablets of Metoprolol Tartrate by New Coprocessed Technique, Research journal of Pharmaceutical, Biological & Chemical Science, 2011; 2(3):385-390.
7. Puglia C, Samad A, Ali A, Aqil M, Sharma M, Mishra AK. Gelrite-based in-vitro gelation ophthalmic drug delivery system of gatifloxacin. J Disp Sci Tech, 2010; 29:89-96.
8. Ramesh Y, Abhirami B, Gnana Sri K, Kaveri S, Neha Sulthana SK, Sravya A.S.L.S.M., Sujatha K, Formulation And Evaluation Of Oxymetazoline Hydrochloride Nasal Gels, Journal of Drug Delivery & Therapeutics, 2018; 8(6):49-57.
9. Radomska, Bonferoni MC, Rossi S, Ferrari F, Güneri T, Caramella C. Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity. Int J Pharm, 2007; 364:76-86
10. Pignatello R, Du YZ, Yuan H, Ye YQ, Zeng S. Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. Colloids Surf B Biointerfaces, 2006; 45:167-173
11. Puglia C, Samad A, Ali A, Aqil M, Sharma M, Mishra AK. Gelrite-based in-vitro gelation ophthalmic drug delivery system of gatifloxacin. J Disp Sci Tech, 2010; 29:89-96
12. Viswanatha Reddy M, Saravana Kumar K, Ramesh Y, Chanukya Kumar G, Venkateswarlu I, Venkatesh R, Preparation And Evaluation Of Quetiapine Fumarate Microspheres, Journal Of Pharmacy Research, 2011; 4(11):41-43.
13. Casadei M.A, Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine- based mixed micelles: preparation and characterization. Int J Pharm, 2010; 340:153-162.
14. Ramesh Y, Sireesha V, Transdermal Patch of Ramipril Loaded Chitosan Nanoparticles Dispersed in Carbopol Gel, Journal of Drug Delivery & Therapeutics, 2017; 7(6):56-65.
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