Physico-chemical Standardization of NPCF (Non-Pharmacopoeial Compound Formulation) Use in Diabetes mellitus

  • Reesha Ahmed P. G Scholar, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India
  • Naeem Ahmad Khan Professor, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India

Abstract

Background: Variety of reasons has been cited for the need for scientific evaluation and standardization of herbal drugs. Three methods, viz., activity-based standardization, determination of biologically active compound and standardization of herbal drugs on various physical, chemical and other parameters were found to be suitable and practically applicable. Phytochemical investigations along with biological screening to understand the therapeutic dynamics of medicinal plants etc. will help in developing quality parameters and help in the standardization and establish for authenticity and quality. Material and methods: Standardization was made on the basis of physicochemical and analytical parameters laid down by National Unani Pharmacopoeia Committee (Anonymous, 2007). Results: The parameters studied includes alcohol soluble content 15.34±0.48    water soluble content  18.27±0.38,  successive extractive values viz. petroleum ether 7.60±0.05 , diethyl ether 1.24±0.02, chloroform 2.24± 0.04 , acetone 4.74±0.02, alcohol 8.51±0.06  , and aqueous 4.20±0.05, non- successive extractive values viz. petroleum ether 6.70±0.06, chloroform  7.70±0.06, alcohol16.15± 0.03 and aqueous 10.65±0.03, total ash  5.50±0.28   , acid   insoluble   ash  2.33±0.33, water soluble ash 1.16±0.16    , moisture   content 7.30±0.12 , Bulk density 0.419±0.005 (pour density) and 0.74±0.01 (Tap density), pH values of 1% solution 4.89±0.01 and 10% solution  4.69±0.005. The qualitative analysis of various phytochemicals was estimated that revealed the presence of alkaloid, carbohydrate, flavonoids, protein, starch, phenols, tannin, sterols, amino acid and resin. The TLC profile of the extracts of non-pharmacopoeial Compound Formulation was also performed which confirms various biomolecules in it.. Conclusion: This study helps in determining the quality and purity of NPCF which is use in Diabetes mellitus.


Keywords: Standardization, Non-Pharmacopoeial Compound formulation, Physico-chemical study

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Author Biographies

Reesha Ahmed, P. G Scholar, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India
  1. P. G Scholar, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India
Naeem Ahmad Khan, Professor, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India

Professor, Department of Ilmul Advia, Ajmal Khan Tibbiya College, A.M.U, Aligarh, India

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How to Cite
Ahmed, R., & Khan, N. A. (2019). Physico-chemical Standardization of NPCF (Non-Pharmacopoeial Compound Formulation) Use in Diabetes mellitus. Journal of Drug Delivery and Therapeutics, 9(1), 154-158. https://doi.org/10.22270/jddt.v9i1.2200