Synthesis of different α, β- unsaturated oxazolone derivatives

  • Pallavi L Phalke Vishal Institute of Pharmaceutical Education & Research. Tal-Junnar, Dist-Pune, Maharashtra 412411

Abstract

Acetyl glycine were prepared from glycine acetic anhydride and then 2, 4-disubstituted Oxazol-5-one were prepared from acetyl glycine, substituted aldehydes, acetic anhydride, and sodium acetate as a catalyst. The formed product is evaluated and characterized by thin layer chromatography, infrared spectroscopy and melting point. The, β- unsaturated shows ability to react with various nucleophilic reagents for synthesis of new fused oxazole compounds.


Keywords: glycine, acetic anhydride, aldehyde Sodium acetate, Oxazolone, E. coli, Antibacterial Activity.

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Author Biography

Pallavi L Phalke, Vishal Institute of Pharmaceutical Education & Research. Tal-Junnar, Dist-Pune, Maharashtra 412411

Vishal Institute of Pharmaceutical Education & Research. Tal-Junnar, Dist-Pune, Maharashtra 412411

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How to Cite
Phalke, P. L. (2019). Synthesis of different α, β- unsaturated oxazolone derivatives. Journal of Drug Delivery and Therapeutics, 9(1), 124-127. https://doi.org/10.22270/jddt.v9i1.2189