Pharmacognostical standardization, formulation and evaluation of tablets incorporated with stem bark of Butea monosperma for anti cancer activity

  • Pragada Venkateswara Rao School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Bura Nagaraju Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda, Telangana, India.
  • Pajjuri Venkanna MAK College of Pharmacy, Moinabad, Hyderabad, Telangana, India.
  • Vasudha Bakshi School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.
  • Narender Boggula School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Abstract

The plant Butea monosperma (Palas) popularly known as 'dhak' or 'palas' and commonly known as ‘Flame of forest’ belongs to family Fabaceae. This herb is indigenous to India. The plant is traditionally reported to possess astringent, bitter, alterative, aphrodisiac, anthelmintic, antibacterial and anti-asthmatic, anthelmintic, anti-conceptive, anti-convulsive, anti-diabetic, anti-diarrhoeal, anti-estrogenic, anti-fertility, anti-microbial, anti-fungal, anti-bacterial, anti-stress, chemopreventive, hepatoprotective. The present research investigation was envisaged on pharmacognostical standardization, formulation and evaluation of tablets incorporated with methanolic extract of stem bark Butea monosperma for anti cancer activity. Conventional release tablets of methanolic extract of Butea monosperma stem bark (MEBMSB) were formulated using Microcrystalline Cellulose as a filler and PVP-k30 as a binder by direct compression method. Finally from this research investigation it can be concluded that methanolic extract of Butea monosperma stem bark has moderate anti-cancer activity when compare to standards and be suggested as a better substitute for the synthetic anti cancer drugs.


Keywords: Butea monosperma, anti cancer activity, MTT assay, EAC cells, DAC cells, HepG2 cell lines.

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Author Biographies

Pragada Venkateswara Rao, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Bura Nagaraju, Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda, Telangana, India.

Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda, Telangana, India.

Pajjuri Venkanna, MAK College of Pharmacy, Moinabad, Hyderabad, Telangana, India.

MAK College of Pharmacy, Moinabad, Hyderabad, Telangana, India.

Vasudha Bakshi, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

Narender Boggula, School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkesar, Telangana, India.

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How to Cite
Rao, P. V., Nagaraju, B., Venkanna, P., Bakshi, V., & Boggula, N. (2019). Pharmacognostical standardization, formulation and evaluation of tablets incorporated with stem bark of Butea monosperma for anti cancer activity. Journal of Drug Delivery and Therapeutics, 9(1), 114-123. https://doi.org/10.22270/jddt.v9i1.2179