Effects of aliskiren on hemodynamic parametersin daunorubicin -induced acute cardiomyopathy in rats

  • Md. Salahuddin Ansari PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India
  • Rohit Saraswat Head, School of Pharmacy OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India
  • Pankaj Sharma Head, School of Pharmacy, Apex University, Jaipur, Rajasthan, India
  • Md. Sarfaraz Alam PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

Abstract

Daunorubicin ((DNR)) used in oncological practice against a wide variety of solid organ tumors and hematologic malignancies, including leukemia, lymphoma, breast cancer, lung cancer, multiple myeloma and sarcoma. however clinical use of this agent is limited due to cardiomyopathy and cardiac heart failure. one of the important player in the development of cardic hypertrophy and reperfusion injury is renin-angiotensin system. Aliskiren (ALK) a recent drug of a direct inhibitor of the renin enzyme. It Protect cardiomyopathy by the inhibition of the renin activity. Present study is towards the evaluation of protective effcets of ALK 50 and 100 mg/kg/day in rats. The systolic, diastolic, mean BP and heart rate were significantly (P< 0.01) increased in DNR control group as compared to normal control group. Thus the results provide clear evidence that the ALK pretreatment offered significant protection against DNR-induced Hemodynamic parameters changes.


 Keywords: Daunorubicin, Cardiomyopathy, Aliskiren, Telmisartan and Hemodynamic parameters

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Author Biographies

Md. Salahuddin Ansari, PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

Rohit Saraswat, Head, School of Pharmacy OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

Head, School of Pharmacy OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

Pankaj Sharma, Head, School of Pharmacy, Apex University, Jaipur, Rajasthan, India

Head, School of Pharmacy, Apex University, Jaipur, Rajasthan, India

Md. Sarfaraz Alam, PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

PhD Research Scholar, School of Pharmacy, OPJS University, Rawatsar Kunjla, Near Sankhu Fort, Rajgarh (Sadulpur) -Jhunjhunu Road, Churu – Rajasthan-331303, India

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How to Cite
Ansari, M. S., Saraswat, R., Sharma, P., & Alam, M. S. (2019). Effects of aliskiren on hemodynamic parametersin daunorubicin -induced acute cardiomyopathy in rats. Journal of Drug Delivery and Therapeutics, 9(1), 103-107. https://doi.org/10.22270/jddt.v9i1.2177

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