Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL

  • Afroza Akbar Patel Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415
  • Siraj N Shaikh Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415
  • Huzaifa Patel Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415
  • Afzal Band Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415
  • Ahmed Shaoor Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

Abstract

The aim of this research work was to design develop & evaluate oral fast disintegrating tablets of Ranitidine HCL. The Orodispersible tablets of Ranitidine HCl were prepared by using direct Compression technique with a Synthetic Superdisintegrant such as Crosspovidone and a natural Superdisintegrant Fenugreek gum in different concentration. 32 factorial designs was applied to study the effect of independent variables,  concentration of Crosspovidone & Fenugreek gum on dependent variables like Cumulative % Drug release and Disintegration time by using design expert software. Prepared oral fast disintegrating tablets evaluated for Pre and Post-compression parameters. The prepared tablets exhibited satisfactory physico-chemical characterise especially fast disintegration & dissolution property. Full factorial design and optimization technique successfully used in the development oral fast disintegrating tablets. Comparing the all the formulations, formulation F9 was considered as optimized formulation which shows excellent fast disintegration, in vitro dissolution, and faster drug release within 6 min in comparison to other batches also stable in stability study.


Keywords:  Fast disintegrating, Ranitidine, Crosspovidone, Gum, Optimizations, Water absorption ratio

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Author Biographies

Afroza Akbar Patel, Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

 Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

Siraj N Shaikh, Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

 Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

Huzaifa Patel, Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

 Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

Afzal Band, Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

 Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

Ahmed Shaoor, Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

 Department of Pharmaceutics, Jamia Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

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How to Cite
Patel, A. A., Shaikh, S. N., Patel, H., Band, A., & Shaoor, A. (2019). Designing fabrication and evaluation of Oral fast Disintegrating tablet of Ranitidine HCL. Journal of Drug Delivery and Therapeutics, 9(1), 95-102. https://doi.org/10.22270/jddt.v9i1.2176