COMPARATIVE IN VITRO DISSOLUTION STUDY OF SPIRONOLACTONE FROM BINARY AND TERTIARY SOLID DISPERSION: MODEL DEPENDANT AND INDEPENDENT APPROACHES
Abstract: In this study solid dispersions (SDs) of spironolactone were prepared by solvent evaporation technique using poloxomer 407, Â kollicoat IR, kollidon VA 64 and PEG 6000 as carrier. The solid dispersions were investigated for drug loading and dissolution behavior. Solid dispersions were found effective to enhance the solubility of spironolactone significantly in the dissolution media. Dissolution test was carried out purified water. Solid dispersion containing kollidon VA 64 at the ratio of 1:20, showed faster and higher drug release and was found most effective among all the solid dispersions. Drug carrier interactions were studied by comparing Fourier Transformed Infrared Spectroscopy (FT-IR) spectra of solid dispersions with pure drug and the SDs were found stable. Dissolution results of all the formulations were compared by using difference factor (f1), similarity factor (f2), dissolution efficiency (%DE) and multiple comparison Bonferroni test. No significant difference was found among the binary SDs containing 1:5 carrier, on the other hand all the ternary SDs were also found similar. So, solid dispersion technique may be an effective technique to enhance dissolution rate of spironolactone.
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