Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation

  • Rinshi Agrawal Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India
  • RK Maheshwari Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India

Abstract

Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime.


Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.

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Author Biographies

Rinshi Agrawal, Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India

Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India

RK Maheshwari, Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India

Department of Pharmacy, Shri G.S. Institute of Technology and Science, Park Road, Indore-452003, Madhya Pradesh, India

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1.
Agrawal R, Maheshwari R. Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation. JDDT [Internet]. 15Dec.2018 [cited 2Feb.2023];8(6-s):5-. Available from: http://jddtonline.info/index.php/jddt/article/view/2167