Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation
Abstract
Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime.
Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.
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References
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15. Maheshwari RK et al; “Solid as solvent”- Novel spectrophotometric analytical method for quantitative estimation of gatifloxacin tablets using solids (eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (mixed solvency concept), European Journal of Biomedical and Pharmaceutical Sciences, 2017; 4(8):644-648.
16. Maheshwari RK, Dahima R, “Solid as solvent”- Novel spectrophotometric analytical technique for quantitative estimation of tinidazole in tablets using solids (eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (mixed solvency concept), Journal of Drug Delivery and Therapeutics, 2017; 7(3):127-130.
17. Rajagopalan R, Formulation and evaluation of tinidazole syrup made by mixed solvency concept, Scholars Research Library, 2012; 4 (1):170-174.
18. Jain R, Maheshwari RK, George P, Formulation development and evaluation of controlled release tablets of lamotrigine using mixed solvency concept, Bulletin of Pharmaceutical Research, 2015; 5(1):9-14.
19. Maheshwari RK, Gupta P, Gupta H, Formulation development of a model dry injection for reconstitution of poorly water soluble drug ornidazole using mixed solvency concept and its evaluation, International Journal of Science and Research, 2018; 7(4):408-414.
20. Padiyar A, Maheshwari RK; Novel dry injection for reconstitution of aspirin using solid solubilizers, Journal of Drug Delivery and Therapeutics, 2017; 7(7):44-45.
21. Patel SK, Maheshwari RK, Formulation development and evaluation of SEDDS of poorly soluble drug made by novel application of mixed-solvency concept, International Journal of Pharmaceutical Research, 2012; 4:51-56.
22. Shilpkar R, Maheshwari RK, Formulation development and evaluation of injection of poorly soluble drug using mixed solvency concep, International Journal of Pharma and Bio Sciences, 2012; 3:179-189.
23. Solanki SS, Soni LK, Maheshwari RK, Study on mixed solvency concept in formulation development of aqueous injection of poorly water soluble drug, Journal of Pharmaceutics, 2013; 4(2):58-61.
24. http://www.centaurpharma.com/pdf/Cefocef-O.pdf
25. http://www.drugbank.ca/drugs/DB00671
2. Satheeshbabu, N.; Gowthamarajan, K.; Gayathri, R. and Saravanan, T., Liquisolid: A Novel Technique to Enhance Bioavailability. Journal of Pharmacy Research.2011; 4(1):181-185.
3. Fahmy, R. H. and Kassem, M. A., Enhancement of Famotidine Dissolution Rate Through Liquisolid Tablets Formulation: In vitro and in vivo Evaluation. European Journal of Pharmaceutics and Biopharmaceutics.2008; 69(3):993-1003..
4. Javadzadeh, Y.; Musaalrezaei, L. and Nokhodchi, A., Liquisolid Technique as a New Approach to Sustain Propranolol Hydrochloride Release from Tablet Matrices. International Journal of Pharmaceutics.2008; 362(1-2):102-108
5. Spireas, S.2002. Liquisolid Systems and Methods of Preparing Same, US6423339B1.
6. Spireas S, Sadu S, and Grover R; In vitro Release Evaluation of Hydrocortisone Liquisolid Tablets. Journal of Pharmaceutical Sciences, 1998; 87(7):867.
7. Maheshwari RK, "Mixed-Solvency" – A novel concept for solubilization of poorly water-soluble drugs, Journal of Technology and Engineering Sciences, 2009; 1(1):39-44.
8. Maheshwari RK Solubilization of Ibuprofen by Mixed-Solvency Approach, The Indian Pharmacist, 2009; 8 (87):81-84.
9. Maheshwari RK, Potentiation of solvent character by mixed-solvency concept: A novel concept of solubilization, Journal of Pharmacy Research, 2010; 3(2):411-413.
10. Maheshwari RK, Upadhyay N, Jain J, Patani M, Mathuria KC, New spectrophotometric estimation of naproxen tablets formulations employing mixed solvency concept (at 331nm), International Journal of Pharmacy & Technology, 2011; 3(4):3618-3621.
11. Maheshwari RK, Fouzdar A, “Solid as solvent”- Novel spectrophotometric analytical technique for ornidazole tablets using solids (eutectic liquid of phenol and niacinamide) as solubilizing agents (mixed solvency concept), Indian Drugs, 2015; 52(06): 42-45.
12. Maheshwari RK, Singh S, George P, Fouzdar A, “Solid as solvent”- novel spectrophotometric analytical technique for satranidazole tablets using solids (eutectic liquid of phenol and niacinamide) as solubilizing agents (mixed solvency concept), International Journal of Innovative Research in Pharmaceutical Sciences, 2015; 1(1):26-29.
13. Jain DK, Patel VK, Bajaj S, Jain N, Maheshwari RK, Novel approach for spectrophotometric estimation of solid dosage forms of tinidazole using solids (eutectic liquid of phenol and niacinamide) as solubilizing agent (mixed solvency concept), World Journal of Pharmacy and Pharmaceutical Sciences, 2015; 4(04):763-769.
14. Jain S et al, Simultaneous estimation of norfloxacin and tinidazole in solid dosage form by uv-spectrophotometry using mixed solvency concept, World Journal of Pharmaceutical and Medical Research, 2018, 4(1):112-117.
15. Maheshwari RK et al; “Solid as solvent”- Novel spectrophotometric analytical method for quantitative estimation of gatifloxacin tablets using solids (eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (mixed solvency concept), European Journal of Biomedical and Pharmaceutical Sciences, 2017; 4(8):644-648.
16. Maheshwari RK, Dahima R, “Solid as solvent”- Novel spectrophotometric analytical technique for quantitative estimation of tinidazole in tablets using solids (eutectic liquid of phenol and lignocaine hydrochloride) as solubilizing agents (mixed solvency concept), Journal of Drug Delivery and Therapeutics, 2017; 7(3):127-130.
17. Rajagopalan R, Formulation and evaluation of tinidazole syrup made by mixed solvency concept, Scholars Research Library, 2012; 4 (1):170-174.
18. Jain R, Maheshwari RK, George P, Formulation development and evaluation of controlled release tablets of lamotrigine using mixed solvency concept, Bulletin of Pharmaceutical Research, 2015; 5(1):9-14.
19. Maheshwari RK, Gupta P, Gupta H, Formulation development of a model dry injection for reconstitution of poorly water soluble drug ornidazole using mixed solvency concept and its evaluation, International Journal of Science and Research, 2018; 7(4):408-414.
20. Padiyar A, Maheshwari RK; Novel dry injection for reconstitution of aspirin using solid solubilizers, Journal of Drug Delivery and Therapeutics, 2017; 7(7):44-45.
21. Patel SK, Maheshwari RK, Formulation development and evaluation of SEDDS of poorly soluble drug made by novel application of mixed-solvency concept, International Journal of Pharmaceutical Research, 2012; 4:51-56.
22. Shilpkar R, Maheshwari RK, Formulation development and evaluation of injection of poorly soluble drug using mixed solvency concep, International Journal of Pharma and Bio Sciences, 2012; 3:179-189.
23. Solanki SS, Soni LK, Maheshwari RK, Study on mixed solvency concept in formulation development of aqueous injection of poorly water soluble drug, Journal of Pharmaceutics, 2013; 4(2):58-61.
24. http://www.centaurpharma.com/pdf/Cefocef-O.pdf
25. http://www.drugbank.ca/drugs/DB00671
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1.
Agrawal R, Maheshwari R. Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation. JDDT [Internet]. 15Dec.2018 [cited 2Feb.2023];8(6-s):5-. Available from: http://jddtonline.info/index.php/jddt/article/view/2167
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