Formulation and evaluation of deflazacort loaded mucoadhesive microsphere for colon drug delivery system

  • Akash Purohit NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India
  • Mithun Bhowmick NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India
  • Jagdish Rathi NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

Abstract

Irritable bowel disease is very common colon disease. Deflazacort is one of the best drug with clinical activity against Irritable bowel disease. Microsphere system are effectively protect drugs against premature degradation, to localize drug molecules at the target site of action and to control the time and rate of release. Mucoadhesive microspheres enhance the bioavailability of orally given drugs by lengthened contact time of drug with the intestinal mucosa. The main disadvantage of these microspheres is adherence to the substrate by non-specific interaction. To overcome this limitation, microspheres are prepared by emulsification method to treat irritable bowel disease. Chitosan microspheres were prepared by Ionotropic Gelation method. Microspheres were coated with Eudragil S using solvent evaporation method.


Keywords: Deflazacort, Mucoadhesive, Microspheres, Irritable bowel disease

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Author Biographies

Akash Purohit, NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

Mithun Bhowmick, NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

Jagdish Rathi, NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

NRI Institute of Pharmaceutical Sciences, Bhopal (M.P), India

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How to Cite
Purohit, A., Bhowmick, M., & Rathi, J. (2019). Formulation and evaluation of deflazacort loaded mucoadhesive microsphere for colon drug delivery system. Journal of Drug Delivery and Therapeutics, 9(1), 79-84. https://doi.org/10.22270/jddt.v9i1.2164

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