Transdermal patches fabricated from hyaluronic acid for the enhanced skin penetration of therapeutic entities
Skin is an attractive route for drug delivery. However poor permeation of drugs across the skin due to the presence of extremely ordered architecture of outermost layer of skin, led to several investigation to improve the permeability of drugs. Polysaccharides remain widely studied biomaterial for the sustained delivery of drug molecules across the skin. The advance of hyaluronic acid (HA) chemistry with multiple benefits has improved the attention of research groups for its application in the skin transportation of drug molecules. Beginning from the advantages of transdermal route, the present review details the application of HA in transdermal drug delivery. In the last few decades, substantial investigation in the domain has improved the requirement for an outline of all the developments, which is depicted in the review. The review also presented different types of HA based transdermal devices such as transferosomes, nanoemulsions, microneedle etc and their potential to improve the transdermal drug delivery. Furthermore the application of HA through chemical modification as a potential transdermal device is also presented.
Keywords: Hyaluronic acid, transdermal drug delivery, microneedles, nanoemulsion, hydrogel
2. Tahara Y, Honda S, Kamiya N, Piao H, Hirata A, Hayakawa E, Fujii T, Goto M. A solid-in-oil nanodispersion for transcutaneous protein delivery. J. Controlled Release. 2008; 131:14−18.
3. Rein H, Experimental electroendosmotic studies on living human cell, Zeitschrift fur Biologie, 1924; 81:125-140.
4. Michaels AS, Chandrasekaran SK, Shaw JE, Drug permeation through human skin: Theory and in vitro experimental measurement, AIChE Journal, 1975; 21:985-996.
5. Lapcik L, Lapčík L, De Smedt S, Demeester J, Chabreček, P, Hyaluronan: Preparation, Structure, Properties, and Applications, Chemical Reviews, 1998; 98:2663-2684.
6. Dosio F, Arpicco S, Stella B, Fattal E, Hyaluronic acid for anticancer drug and nucleic acid delivery, Advanced Drug Delivery Reviews, 2016; 97:204-236.
7. Witting, M., Boreham, A., Brodwolf, R., Vavrova, K., Alexiev, U., Friess, W., Hedtrich, S., Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules, Molecular Pharmaceutics, 2015; 12:1391-1401.
8. Yang JA, Kim ES, Kwon JH, Kim H, Shin JH, Yun SH et al., Transdermal delivery of hyaluronic acid – Human growth hormone conjugate, Biomaterials, 2012; 33:5947-5954.
9. El-Refaie WM, Elnaggar YSR, El-Massik MA, Abdallah OY, Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: In-vitro ptimization, Ex-vivo and In-vivo Permeation, Pharmaceutical Research, 2015; 32:2901-2911.
10. Lim HJ, Cho EC, Lee JA, Kim J, A novel approach for the use of hyaluronic acid-based hydrogel nanoparticles as effective carriers for transdermal delivery systems, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012; 402:80-87.
11. Wei S, Xie J, Luo Y, Ma Y, Tang S, Yue P, Yang M, Hyaluronic acid based nanocrystals hydrogels for enhanced topical delivery of drug: A case study, Carbohydrate Polymers, 2018; 202:64-71.
12. Cilurzo F, Vistoli G, Gennari CGM, Selmin F, Gardoni F, Franzè S et al., The Role of the Conformational Profile of Polysaccharides on Skin Penetration: The Case of Hyaluronan and Its Sulfates, Chemistry & Biodiversity, 2014; 11:551-561.
13. Franzé S, Marengo A, Stella B, Minghetti P, Arpicco S, Cilurzo F, Hyaluronan-decorated liposomes as drug delivery systems for cutaneous administration, International Journal of Pharmaceutics, 2018; 535:333-339.
14. Gao Y, Cheng X, Wang Z, Wang J, Gao T, Li P, Transdermal delivery of 10,11-Methylenedioxycamptothecin by hyaluronic acid based nanoemulsion for inhibition of keloid fibroblast, Carbohydrate Polymers, 2014; 112:376-386.
15. Kong M, Park HJ, Stability investigation of hyaluronic acid based nanoemulsion and its potential as transdermal carrier, Carbohydrate Polymers, 2011; 83:1303-1310.
16. Kong M,. Chen XG, Kweon DK, Park HJ, Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier, Carbohydrate Polymers, 2011; 86: 837-843.
17. Jung HS, Kong WH, Sung DK, Lee MY, Beack SE, Keum DH et al., Nanographene Oxide_Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer, ACS Nano, 2014; 8:260-268.
18. Kim KS, Kim H, Park Y, Kong WH, Lee SW, Kwok SJJ et al., Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant, Advanced Functional Materials, 2016; 26:2512-2522.
19. Kong M, Hou L, Wang J, Feng C, Liu Y, Cheng X et al., Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy, Chemical Communications, 2015; 51:1453-1456.
20. Kong M, Park H, Feng C, Hou L, Cheng X, Chen X, Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy, Carbohydrate Polymers, 2013; 94:634-641.
21. Kim AR, Lee SL, Park SN, Properties and in vitro drug release of pH- and temperaturesensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin, International Journal of Biological Macromolecules, 2018; 118:731-740.
22. Manca ML, Castangia I, Zaru M, Nácher A, Valenti D, Fernàndez-Busquets X et al., Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring, Biomaterials, 2015; 71:100-109.
23. Martin M, Azoia NG, Shimanovich U, Matamá T, Gomes AC, Silva C et al., Design of Novel BSA/Hyaluronic Acid Nanodispersions for Transdermal Pharma Purposes, Molecular Pharmaceutics, 2014; 11:1479-1488.
24. Šmejkalová D, Muthný T, Nešporová K, Hermannová M, Achbergerová E, Huerta-Angeles G et al., Hyaluronan polymeric micelles for topical drug delivery, Carbohydrate Polymers, 2017; 156:86-96.
25. Berkó S, Maroda M, Bodnár M, Erős G, Hartmann P, Szentner K et al., Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems, European Polymer Journal, 2013; 49:2511-2517.
26. Kong BJ, Kim A, Park SN, Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin, Carbohydrate Polymers, 2016; 147:473-481.
27. Xie J, Ji Y, Xue W, Ma D, Hu Y, Hyaluronic acid-containing ethosomes as a potential carrier for transdermal drug delivery, Colloids and Surfaces B: Biointerfaces, 2018; 172:323-329.
28. Yang JA, Kim ES, Kwon JH, Kim H, Shin JH, Yun SH et al., Transdermal delivery of hyaluronic acid e Human growth hormone conjugate, Biomaterials, 2012; 33:5947-5954.
29. Yue Y, Zhao D, Yin Q, Hyaluronic acid modified nanostructured lipid carriers for transdermal bupivacaine delivery: In vitro and in vivo anesthesia evaluation, Biomedicine & Pharmacotherapy, 2018; 98:813-820.
30. Choi JT, Park SJ, Park JH, Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behavior after administration into skin, Journal of Drug Targeting, 2018; 26:884-894.
31. Kim S, Lee J, Shayan FL, Kim S, Huh I, Ma Y et al., Physicochemical study of ascorbic acid 2-glucoside loaded hyaluronic acid dissolving microneedles irradiated by electron beam and gamma ray, Carbohydrate Polymers, 2018; 180:297-303.
32. Matsuo K, Okamoto H, Kawai Y, Quan Y, Kamiyama F, Hirobe S et al., Vaccine efficacy of transcutaneous immunization with amyloid β using a dissolving microneedle array in a mouse model of Alzheimer's disease, 2014; 266:1-11
33. Wu D, Quan Y, Kamiyama F, Kusamori K, Katsumi H, Sakane T, et al., Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats, Biological and Pharmaceutical Bulletin, 2015; 38:365-373.
34. Liu S, Wu D, Quan YS, Kamiyama F, Kusamori K, Katsumi H et al., Improvement of Transdermal Delivery of Exendin‑4 Using Novel Tip-Loaded Microneedle Arrays Fabricated from Hyaluronic Acid, Molecular Pharmaceutics, 2016; 13:272-279.
35. Liu S, Jin MN, Quan YS, Kamiyama F, Katsumi H, Sakane T et al., The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin, Journal of Controlled Release, 2012; 161:933-941.
36. Yu W, Jiang G, Zhang Y, Liu D, Xu B, Zhou J, Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin Materials Science and Engineering: C, 2017; 80:187-196.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).