The spectrum of adverse drug reactions in a multidisciplinary kidney clinic
Abstract
Introduction: Data on adverse drug-reactions (ADR) in the medical field are rare. Objective: To report on the pattern of such problem in a multidisciplinary kidney clinic Patients and Methods: Medical records of patients were reviewed retrospectively for such phenomenon in the past 6 years Results: A total of 4834 patients were included for analysis. The unit is responsible for a large proportion of patients with acute and chronic kidney diseases of diverse etiologies and multiple co-morbid conditions. Acute and maintenance dialysis as well as immunosuppressive treatment for idiopathic glomerulopathy and autoimmune systemic diseases were common practice. Results: A total of 70044 ADR were diagnosed in 4438 patients. Most patients were adults (39+14) and had median follow up of 38 months. Nearly half of the ADR were due to drug-side effects while idiosyncrasy accounted for 1.2%. The former is due to misuse/abuse of medications while the latter is due to genetic, co-morbid conditions or synergetic between 2 drugs or a drug and disease. Details of drugs ADR are outlined with their respective prevalence. Our study indicates the need for careful auditing of patient’s response during follow up to improve their drug-compliance.
Keywords: adverse drug reaction, allergy, medical clinic, kidney disease.
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