OXCARBAZEPINE-INDUCED TOXIC EPIDERMAL NECROLYSIS: A CASE REPORT

  • Umashanker PD Keshri DEPARTMENT OF PHARMACOLOGY,RIMS, RANCHI

Abstract

ABSTRACT

A 66 year old lady admitted to medical college hospital presented with complaints of skin rashes and itching. Past history of the patient revealed that she was on tablet digoxin and sodium valproate.  Tablet oxcarbazepine was added by a physician one week back for better control of seizure. Rashes spread on face, eyelid, lip, mouth, neck, limbs, abdomen; in 2/3 parts of her body. Subsequently rashes changed to vesicle and ulcer. Patient recovered after stopping oxcarbazepine. Investigation reports revealed leucocytosis, elevated C - reactive protein and full thickness necrosis of epidermis, confirming the diagnosis of toxic epidermal necrolysis (TEN). She was treated mainly by corticosteroid, antihistaminic and antimicrobial and improved. Time taken for resolution of the lesion was 38 days. Rechallenge with the offending drug was not done in the interest of patient and due to ethical constraints.

KEY WORDS: Oxcarbazepine, Toxic epidermal necrolysis.

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Author Biography

Umashanker PD Keshri, DEPARTMENT OF PHARMACOLOGY,RIMS, RANCHI
Assistant professor,Department of pharmacology.
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1.
Keshri U. OXCARBAZEPINE-INDUCED TOXIC EPIDERMAL NECROLYSIS: A CASE REPORT. JDDT [Internet]. 15Jul.2012 [cited 24Sep.2020];2(4). Available from: http://jddtonline.info/index.php/jddt/article/view/216