Chitosan anchored nanoparticles for breast cancer: preparation and evaluation: part-I

  • Rajkumari Thagele Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India
  • Archana Bagre Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India
  • Mohan Lal Kori Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Abstract

The objective of present research work was to develop methotrexate loaded chitosan anchored shell nanoparticles for drug delivery in breast cancer. Chitosan nanoparticles (CS-NPs) were synthesized by ionic gelation of chitosan using sodium tripolyphosphate (STPP). The optimized nanoparticles were characterized for particle size and polydispersity index (PDI) revealed particle size were found to be between 57.08 nm to169.5 nm and PDI 0.252 to 0.639 respectively. The results signpost that stirring speed during ionic gelation reaction was also decisive parameters for the size of the nanoparticles obtained. Further characterization involved to show polymer-drug interaction was FTIR and DSC. This paper grants a revision of the physical factors elaborate in attaining nanoparticles in order to regulate the particle size of polymeric nanoparticles made from chitosan, without any surplus chemical treatment.


Keywords: Breast cancer, Nanoparticles, Chitosan, Methotrexate

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Author Biographies

Rajkumari Thagele, Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Archana Bagre, Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Mohan Lal Kori, Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

Vedica College of B. Pharmacy, RKDF University, Gandhi Nagar, Bhopal (M.P.) – India

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How to Cite
Thagele, R., Bagre, A., & Kori, M. L. (2019). Chitosan anchored nanoparticles for breast cancer: preparation and evaluation: part-I. Journal of Drug Delivery and Therapeutics, 9(1), 1-5. https://doi.org/10.22270/jddt.v9i1.2151