Development and optimization of orodispersible tablets using solid dispersion of Telmisartan
The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of Telmisartan and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of ODT system. A batch process was adopted for the preparation of solid dispersion with each combination of drug and polymer and the finally compressed as tablets by direct compression technique. For the preformulation perspective materials were scrutinized on the basis of solubility profile, drug content, Fourier Transform Infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). The drug polymer ratio 1:4 was selected for further compression process. The prepared batches of ODTs were characterized for micromeritic study, thickness, hardness, weight variation, wetting time, disintegration time, drug content and in vitro drug release profile. The evaluation data for all batches was satisfactory out of them formulation TF3 containing 6% kyron T-314 showed the best results with a value of 29.3 sec and 24.1 sec for wetting and disintegration, respectively. This formulation showed superior drug release of 99.93% over a period of 30 minutes.
2. Deshmukh KR, Jain SK, Development of aceclofenac mouth dissolving tablets using solid dispersion technique: in-vitro evaluation, Indian Journal of Pharmaceutical Education and Research, 2012; 46(2):97-104.
3. Ali A, Sharma SN, Preparation and evaluation of solid dispersions of ibuprofen, Indian Journal of Pharmaceutical Sciences, 1991; 53(6):233-236.
4. Rao KRSS, Nagabhushanam MV, Chowdary KPR, In vitro dissolution studies on solid dispersion of mefanamic acid, Indian Journal of Pharmaceutical Sciences, 2011; 73(1):243-247.
5. Chaulang G, Patel P, Hardikar S, Kelkar M, Bhosale A, Bhise S, Formulation and evaluation of solid dispersions of furosemide in sodium starch glycolate, Tropical Journal of Pharmaceutical Research, 2009; 8(1):43-51.
6. Kausalya J, Suresh K, Padmapriya S, Solubility and dissolution enhancement profile of telmisartan using various techniques, International Journal of Pharm Tech Research 2011; 3(3):1737-1749.
7. Lindgren S, Janzon L, Dysphagia: prevalence of swallowing complaints and clinical finding, Medical Clincs of North America, 1993; 77:3–5.
8. Habibh, W, Khankarik, R, Hontz, J, Fast-dissolve drug delivery system, Critical Reviews in Therapeutic Drug Carrier Systems, 2000; 17(3):61–72.
9. Douroumis D, Practical approaches of taste masking technologies in oral solid forms, Expert Opinion on Drug Delivery, 2007; 4:417–426.
10. Akiladevi D, Shanmugapandiyan P, Jebasingh D, Basak A, Preparation and evaluation of paracetamol by solid dispersion technique, Indian Journal of Pharmaceutical Sciences, 2011; 3(1):188-191.
11. Prajapati ST, Gohel MC, Patel LD, Studies to enhance dissolution properties of carbamazepine, Indian Journal of Pharmaceutical Sciences, 2007; 69(3):427-430.
12. Divya B, Sabitha P, Reddy R, Reddy MKK, Rao BN, An approach to enhance solubility of gatifloxacin by solid dispersion technique, Asian Journal of Research in Pharmaceutical Sciences, 2012; 2(2):58-61.
13. Sethia, S, Squillante, E, Physicochemical characterization of solid dispersions of carbamazepine formulated by supercritical carbon dioxide and conventional solvent evaporation method, Journal of Pharmaceutical Sciences, 2002; 91:1948–1957.
14. Lachman L, Herbert AL, Joseph LK. The theory and practice of industrial pharmacy. Bombay: Varghese publishing house; 2008. P. 430-455.
15. Gohel M, Patel M, Amin A, Agrawal A. Dave R, Bariya N, Formulation Design and Optimization of Mouth Dissolve Tablets of Nimesulide Using Vacuum Drying Technique, AAPS Pharm Sci Tech, 2004; 5(3):1-6.
16. Karthikeyan M., Mukhthar Umarul AK, Megha M, Shadeer Hamza P, Formulation of Diclofenac tablets for rapid pain relief, Asian Pacific Journal of Tropical Biomedicine 2012; 2:308-311.
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