Anti-bacterial activity, anti-cancer activity and nanofiber formation of certain poly (ester amides) from 2,5-pyridine dicarboxylic acid

  • V. Chitra Research Scholar, PG &Research Department of Chemistry, Presidency College, University of Madras,Chennai-600 005, India
  • D. Roop Singh Head & Associate Professor, PG & Research Department of Chemistry, Presidency College, University of Madras, Chennai-600 005, India

Abstract

A new series of four poly(ester amides) were synthesized by direct polycondensation of 2,5-pyridine dicarboxylic acid  with two different varying diols and diamines in pyridine medium using diphenylchlorophosphate as a condensation agent. The two diamines employed in the synthesis were 4,4’-diamino diphenyl methane and 1,4-diamino benzene. The arylidenediols 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone and 2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone were also used. The synthesized poly(ester amides) were characterized by qualitative solubility test, FT-IR, 1H and 13C-NMR spectra. The monomeric moieties were found by spectroscopic analysis to be well incorporated in the polymer back bone. The thermal phase transition behavior of the poly(ester amides) were investigated by differential thermo gravimetry (DTG). The nanofibers of synthesized poly(ester amides) with PVC and composite fibers with PVC/nanoclay were formed by electrospinning.  The morphology of these composite fibers was studied by scanning electron microscopy (SEM). These poly(ester amides) were screened for their anti-bacterial potential in vitro against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. In vitro anti-cancer activities of synthesized polymers were also evaluated against MCF7 human breast carcinoma cells. The results show that the polymers exhibited significant anti-bacterial and anti-cancer activity.


Keywords: Poly (ester amides), Anti-bacterial activity, Nano fiber, Anticancer activity

Downloads

Download data is not yet available.

Author Biographies

V. Chitra, Research Scholar, PG &Research Department of Chemistry, Presidency College, University of Madras,Chennai-600 005, India

Research Scholar, PG &Research Department of Chemistry, Presidency College, University of Madras,Chennai-600 005, India

D. Roop Singh, Head & Associate Professor, PG & Research Department of Chemistry, Presidency College, University of Madras, Chennai-600 005, India

Head & Associate Professor, PG & Research Department of Chemistry, Presidency College, University of Madras, Chennai-600 005, India

References

1. Edlund U, Albertsson AC, Polyesters based on diacid monomers, Advanced Drug Delivery Reviews, 2003; 55:585-609.
2. Mingxiao D, Jun W, Cynthia A, Reinhart-king, Chih-Chang Chu, Synthesis and Characterization of Biodegradable Poly(ester amide)s with Pendant Amine Functional Groups and In Vitro Cellular Response , Biomacromolecules, 2009; 10:3037-3047.
3. Manjunatha M, Jagadish RL, Gowda DV, Mohammed SK, Synthesis and Characterization of Poly Ester Amide Polymer for Drug Delivery Applications, International Journal of Pharma and Bio Sciences, 2010; 1:93-106.
4. Murase SK, Puiggali J, Poly(Ester Amide)s: Recent Developments on Synthesis and Applications, 2014; 145-166.
5. Ulery BD, Nair LS, Laurencin CT, Biomedical Applications of Biodegradable Polymers, Journal of Polymer Science Part B: Polymer Physics 2011; 49:832-864.
6. Thatte S, Datar K, Ottenbrite RM, Perspectives On: Polymeric Drugs and Drug Delivery Systems, Journal of Bioactive and Compatible Polymers, 2005; 20:585-601.
7. Nair LS, Laurencin CT, Biodegradable polymers as biomaterials, Progress in Polymer Science, 2007; 32:762-798.
8. Dimmock JR, Padmanilayam MP, Zello GA, Nienaber KH, Allen TM, Santos CL, Clercq ED, Balzarini J, Manavathu EK, Stables JP, Cytotoxic analogues of 2,6-bis(arylidene) cyclohexanones, European Journal of Medicinal Chemistry, 2003; 38:169-177.
9. Abdullah MA, Zagho MM, Elzatahry AA, Polymer-Based Electrospun Nanofibers for Biomedical Applications, Nanomaterials, 2018; 8:259.
10. Malinova L, Stolinova M, Lubasova D, Martinova L, Brozek J, Electrospinning of Polyesteramides based on ɛ-caprolactam and ɛ-caprolactone from solution , European Polymer Journal, 2013; 49:3135-3143.
11. Murali M, Samui AB, Bisbenzylidene cycloalkanone: a versatile molecule as a polymer building block, Journal of Materials Chemistry, 2010; 20:2714-2737.
12. Fonseca AC, Serra AC, Coelho JF, Bioabsorbable polymers in cancer therapy: latest developments, The EPMA Journal, 2015; 6(22):1-18.
13. Mayavathi M, Chitra V, Sathish P, Roop singh D, International Journal of ChemTech Research, 2015; 7:2456-2462.
14. Mosmann T, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity tests, Journal of Immunological Methods, 1983; 65:55-63.
15. Senthilraja P , Kathiresan K, In vitro cytotoxicity MTT assay in Vero, HepG2 and MCF-7 cell lines study of Marine Yeast , Journal of Applied Pharmaceutical Science, 2015; 5(03):080-084.
16. Rajakumar P, Ganesan K, Jayavelu S, Murugesan K, Synthesis and Antibacterial activity of dendritic architectures, Synthesis, 2006; 3:528-532.
Crossmark
Statistics
1458 Views | 546 Downloads
How to Cite
1.
Chitra V, Singh DR. Anti-bacterial activity, anti-cancer activity and nanofiber formation of certain poly (ester amides) from 2,5-pyridine dicarboxylic acid. JDDT [Internet]. 15Dec.2018 [cited 29Mar.2024];8(6-s):166-73. Available from: https://jddtonline.info/index.php/jddt/article/view/2107