Evaluation of antihyperlipidemic activity of ethanolic root extract of Glycyrrhiza glabra Linn.

  • Priya Tyagi Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.
  • Satish Kumar Sharma Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.
  • Pawan Kumar Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Abstract

Glycyrrhiza glabra Linn. is an Indian medicinal plant demonstrated to exert multiple health cures. This plant grows naturally in tropical, subtropical and temperate regions. It is traditionally used as anti-acne, anti-arthritic, anti-convulsant, anti-diabetic, anti-microbial, anti inflammatory, wound healing, anti-oxidant, anti-platelet, anti-stress and nootropic, anti-viral, diuretic and gastroprotective. The antihyperlipidemic effect of ethanolic root extracts of Glycyrrhizaglabrawas studied in wistar rats using High Fat Diet (FD) induced hyperlipidemic model, at the doses of 400 mg/kg body weight. The efficacy of extract was compared with standard drug simvastatin. The ethanolic extracts, significantly decreased the serum lipid profile level in a dose dependent manner in wistar rats. Ethanolic extracts at 400 mg/kg have shown significant antihyperlipidemic action. These results support the fact that this plant is used traditionally as antihyperlipidemic. The study will help in exploring new plant source as an antihyperlipiedemic agent which can minimize the risk and side effects as compared to that of conventional medicine. 


Keywords: Glycyrrhizaglabra, Antihyperlipidemic Activity, Simvastatin, High Fat Diet (FD) induced hyperlipidemic model.

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Author Biographies

Priya Tyagi, Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Satish Kumar Sharma, Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Pawan Kumar, Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

Department of Pharmacology, Sunder Deep Pharmacy College, NH-24, Delhi-Hapur Road, Dasna Ghaziabad, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, india.

References

1. Fredrick L. Dunn. Hyperlipidemia in diabetes mellitus. Wiley online library; Diabetes Metabolism Research and Review. 1990; 6(1):47-61.
2. Manash P. Borgohain, Mangala Lahkar, Sahabuddin Ahmed, Liakat Chowdhury, Saurabh Kumar, Rajat Pant and Abhinav Choubey, Small Molecule Inhibiting Nuclear Factor‐kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan‐Induced Diabetic Nephropathy in Rat, Basic & Clinical Pharmacology & Toxicology, 2017; 120(5):(442-449.
3. Abubakar SM, Umar SA, Alexander I, Abubakar N, Abdulazeez MA, Sule MS, Evaluation of hypoglycaemic, hypolipidaemic and non toxic effect of hydro-methanolic extracts of Ziziphus mauritiana, Ziziphus spina christi fruit and glibenclamide on alloxan induced diabetic rats, Journal of Drug Delivery and Therapeutics. 2018; 8(3):82-92 DOI: http://dx.doi.org/10.22270/jddt.v8i3.1711
4. Yusuf S, Reddy S, Ounpuu, S, Anand, S., Global burden of cardiovascular diseases: Part I: General Considerations, The Epidemiologic Transition, risk factors, and impact of urbanization. Circulation, 2001; 104:2746-3.
5. Ahmad N, Bhopal R. A systematic review based on ECG defined coronary heart disease. Heart, 2005; 91:719-5.
6. Zhang R, Ma J, Xia M, Zhu H, Ling W. Hyperhomocysteinemia induced by feeding rats diet rich in methionine or deficient in folate promotes early atherosclerotic inflammatory process. J Nutr, 2004; 134(4):825.
7. Raman Jegadeesha b, Nanjian Raamana, et al. Hypolipidemic Effect of Pleurotus djamor var. roseus in Experimentally Induced Hypercholesteromic Rats. RJPBCS, 2014; 5(2):.581-587.
8. Chopra RN, Nayar SL, and Chopra IC, Glossary of Indian Medicinal Plants. New Delhi: NISCAIR, CSIR, 2002; 506-508.
9. Okwu DE., "Evaluation of the chemical composition of indigenous spices and flavouring Agents." Global J. Pure Appl. Sci., 2001; 7(3): 455- 459.
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1.
Tyagi P, Sharma SK, Kumar P. Evaluation of antihyperlipidemic activity of ethanolic root extract of Glycyrrhiza glabra Linn. JDDT [Internet]. 15Dec.2018 [cited 27Jan.2021];8(6-s):120-4. Available from: http://jddtonline.info/index.php/jddt/article/view/2098