A comprehensive review on Liposomes: a novel drug delivery system
Abstract
Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug (amphiphatic nature) to its compartment and lead to controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are used for the treatment of various diseases like tumors or cancer. This article provides an overview of Liposomal Drug Delivery System and various aspects related to liposome that can be studied.
Keywords: Liposomes, novel delivery, amphiphatic, controlled release.
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References
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2. Bangham AD and RW Horne. “J Mol Biol”, 1964; 8: 660–668.
3. Lasic, D.D. Novel application of liposomes. Tibitech. 1998; 16:307-321.
4. Mayer, L.D., Hope, M.J., Cullis, P.R., Janoff, A.S. Solute distributions and trapping efficiencies observed in freeze-thawed multilmellar vesicles. Biochim. Biophys. Acta 1985; 817:193-196.
5. 21. Vyas, S.P., Khar, R.K. 2006. Targeted And Controlled Drug Delivery: Novel Carrier Systems. Edition 1, CBS Publishers and Distributor, New Delhi.pp.421-427.
6. Maurya SD, Prajapati S, Gupta A, Saxena G, Dhakar RC, Formulation development and evaluation of ethosome of stavudine, Int J Pharm Edu Res. 2010; 13(16).
7. Chen X, Huang W, Wong BC, Yin L, Wong YF, Xu M, ET al. Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Int J Nanomed, 2012; 7:1139-1148.
8. Fujisawa T, Miyai H, Hironaka K, Tsukamoto T, Tahara K, Tozuka Y, et al. Liposomal diclofenac eye drop formulations targeting the retina: formulation stability improvement using surface modification of liposomes. Int J Pharm, 2012; 436: 564-567.
9. Vishvakrama, P., & Sharma, S. Liposomes: an overview. Journal of Drug Delivery and Therapeutics, 2014; 47-55. https://doi.org/10.22270/jddt.v0i0.843
10. Samadikhah HR, Majidi A, Nikkhah M, Hosseinkhani S. Preparation, characterization, and efficient transfection of cationic liposomes and nanomagnetic cationic liposomes. Int J Nanomedicine, 2011; 6: 2275-2283.
11. Paecharoenchai O, Niyomtham N, Apirakaramwong A, Ngawhirunpat T, Rojanarata T, Yingyongnarongkul BE, et al. Structure Relationship of Cationic Lipids on Gene Transfection Mediated by Cationic Liposomes. AAPS Pharm Sci Tech, 2012; in press.
12. Li X, Chen D, Le C, Zhu C, Gan Y, Hovgaard L. Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake. Int J Nanomedicine, 2011; 6: 3151-3162.
13. Ejiogu Deborah Chioma. Formulation and evaluation of etodolac niosomes by modified ether injection technique. Universal Journal of Pharmaceutical Research. 2016; 1(1): 1-6.
14. Elsaied Hamada Elsaied, Hamdy Mohamed Dawaba, Elsherbini Ahmed Ibrahim, Mohsen Ibrahim Afouna . Investigation of proniosomes gel as a promising carrier for transdermal delivery of Glimepiride. Universal Journal of Pharmaceutical Research. 2016; 1(2): 1-18.
15. Sipai Altaf Bhai. M*, Vandana Yadav, Mamatha. Y, Prasanth V.V Department of pharmaceutics Gautam college of Pharmacy,Lipoosmes an Overview,Journal of pharmaceutical and Scientific innovation,accepted on 24/01/12.
16. Kant Shashi*, Kumar Satinder, Prashar Bharat ,A complete review on liposomes ,International Research Journal Of Pharmacy ISSN 2230-8407
17. Sharma Vijay K ,Liposomes present prospective and future challenges ,International journal of current pharmaceutical review and Research Vol 1,Issue 2 , Aug-Oct-2010 ISSN :0976 822 X
18. Formulation and evaluation of liposomal drug delivery system of decitabine T. Veena* Dr. Manichandrik , Madav, Madhuri , Mounika , Bindu Rani , Ashwini Formulation and evaluation of liposomal drug delivery system of decitabine, Vol 6,Issue 3 , July -Sep 2017.
19. Nasim Karami1, Eskandar Moghimipour2,3, Anayatollah Salimi2,3 Liposomes as a Novel Drug Delivery System: Fundamental and Pharmaceutical Application.
20. Kaur D., Kumar S., Niosomes: present scenario and future aspects. Journal of Drug Delivery and Therapeutics, 2018; 8(5):35-43. https://doi.org/10.22270/jddt.v8i5.1886
21. Hong MS et al., Prolonged blood circulation of methotrexate by modulation of liposomal composition, Drug Delivery 2001; 8:231–237
22. Jesorka A, al., Liposomes: technologies and analytical applications, Annu. Rev. Anal. Chem. 1 (2008) 801–832
23. Vemuri S, et al., Preparation and characterization of liposomes as therapeutic delivery systems: a review, Pharm. Acta Helv. 1995; 70:95–111
24. James ND, et al., Liposomes doxorubicin (Doxil): an effective new treatment for Kaposi’s sarcoma in AIDS, Clin. Oncol.(R. Coll. Radiol.) 1994; 6(5):294–296
25. Laouini A et al., Preparation, characterization and applications of liposomes: state of the art, J. Colloid Sci. Biotechnol. 2012; 1:147–168.
26. Gregoriadis G, et al., Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells, Biochem. Biophys. Res. Commun. 1979; 89:1287–1293.
27. Shailesh S, Neelam S, Sandeep K, Gupta GD, Liposomes: A review, Journal of Pharmacy Research 2009; 2(7):1163-1167.
28. Deshmukh RR, Gawale SV, Bhagwat MK, Ahire PA, Derle ND, A Review on: liposomes, World journal of pharmacy and pharmaceutical sciences, Issue 03, 506-517.
29. Godbole MD, Mathur VB, Selection of phospholipid and method of formulation for optimum entrapment and release of lamivudine from liposome. Journal of Drug Delivery and Therapeutics, 2018; 8(5-s):175-183. https://doi.org/10.22270/jddt.v8i5-s.1935
30. John DF, Yunus AA, Chigbo UJ, Paul US, Ikenna E. Tolnaftate loaded liposomes-design, and in-vitro evaluation. Universal Journal of Pharmaceutical Research. 2016; 1(2): 48-53.
31. Anwekar H, Patel S, Singhai AK, Liposomes as drug carriers , International journal of Pharmacy and life sciences, July 2011.
32. Dwivedi C, Yadav R, Tiwari SP, Satapathy T, Roy A, Role of liposomes in novel drug delivery system, Journal of drug delivery and therapeutics 2014; 4(2):116-129.
33. Priyanka R Kulkarni, Jaydeep D Yadav, Kumar A Vaidya. Liposomes: A Novel Drug Delivery System. International journal of current Pharmaceutical and Research 2011; 3(2).
34. Yadav Y, Kumar S , Pandey D, Dutta RK, Liposomes for drug delivery ,Journal of Biotechnology and Biomaterials , 2017.
35. Ugochukwu AE, Nnedimkpa OJ, Rita NO. Preparation and characterization of Tolterodine tartrate proniosomes, Universal Journal of Pharmaceutical Research. 2017; 2(2):22-25.
2. Bangham AD and RW Horne. “J Mol Biol”, 1964; 8: 660–668.
3. Lasic, D.D. Novel application of liposomes. Tibitech. 1998; 16:307-321.
4. Mayer, L.D., Hope, M.J., Cullis, P.R., Janoff, A.S. Solute distributions and trapping efficiencies observed in freeze-thawed multilmellar vesicles. Biochim. Biophys. Acta 1985; 817:193-196.
5. 21. Vyas, S.P., Khar, R.K. 2006. Targeted And Controlled Drug Delivery: Novel Carrier Systems. Edition 1, CBS Publishers and Distributor, New Delhi.pp.421-427.
6. Maurya SD, Prajapati S, Gupta A, Saxena G, Dhakar RC, Formulation development and evaluation of ethosome of stavudine, Int J Pharm Edu Res. 2010; 13(16).
7. Chen X, Huang W, Wong BC, Yin L, Wong YF, Xu M, ET al. Liposomes prolong the therapeutic effect of anti-asthmatic medication via pulmonary delivery. Int J Nanomed, 2012; 7:1139-1148.
8. Fujisawa T, Miyai H, Hironaka K, Tsukamoto T, Tahara K, Tozuka Y, et al. Liposomal diclofenac eye drop formulations targeting the retina: formulation stability improvement using surface modification of liposomes. Int J Pharm, 2012; 436: 564-567.
9. Vishvakrama, P., & Sharma, S. Liposomes: an overview. Journal of Drug Delivery and Therapeutics, 2014; 47-55. https://doi.org/10.22270/jddt.v0i0.843
10. Samadikhah HR, Majidi A, Nikkhah M, Hosseinkhani S. Preparation, characterization, and efficient transfection of cationic liposomes and nanomagnetic cationic liposomes. Int J Nanomedicine, 2011; 6: 2275-2283.
11. Paecharoenchai O, Niyomtham N, Apirakaramwong A, Ngawhirunpat T, Rojanarata T, Yingyongnarongkul BE, et al. Structure Relationship of Cationic Lipids on Gene Transfection Mediated by Cationic Liposomes. AAPS Pharm Sci Tech, 2012; in press.
12. Li X, Chen D, Le C, Zhu C, Gan Y, Hovgaard L. Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake. Int J Nanomedicine, 2011; 6: 3151-3162.
13. Ejiogu Deborah Chioma. Formulation and evaluation of etodolac niosomes by modified ether injection technique. Universal Journal of Pharmaceutical Research. 2016; 1(1): 1-6.
14. Elsaied Hamada Elsaied, Hamdy Mohamed Dawaba, Elsherbini Ahmed Ibrahim, Mohsen Ibrahim Afouna . Investigation of proniosomes gel as a promising carrier for transdermal delivery of Glimepiride. Universal Journal of Pharmaceutical Research. 2016; 1(2): 1-18.
15. Sipai Altaf Bhai. M*, Vandana Yadav, Mamatha. Y, Prasanth V.V Department of pharmaceutics Gautam college of Pharmacy,Lipoosmes an Overview,Journal of pharmaceutical and Scientific innovation,accepted on 24/01/12.
16. Kant Shashi*, Kumar Satinder, Prashar Bharat ,A complete review on liposomes ,International Research Journal Of Pharmacy ISSN 2230-8407
17. Sharma Vijay K ,Liposomes present prospective and future challenges ,International journal of current pharmaceutical review and Research Vol 1,Issue 2 , Aug-Oct-2010 ISSN :0976 822 X
18. Formulation and evaluation of liposomal drug delivery system of decitabine T. Veena* Dr. Manichandrik , Madav, Madhuri , Mounika , Bindu Rani , Ashwini Formulation and evaluation of liposomal drug delivery system of decitabine, Vol 6,Issue 3 , July -Sep 2017.
19. Nasim Karami1, Eskandar Moghimipour2,3, Anayatollah Salimi2,3 Liposomes as a Novel Drug Delivery System: Fundamental and Pharmaceutical Application.
20. Kaur D., Kumar S., Niosomes: present scenario and future aspects. Journal of Drug Delivery and Therapeutics, 2018; 8(5):35-43. https://doi.org/10.22270/jddt.v8i5.1886
21. Hong MS et al., Prolonged blood circulation of methotrexate by modulation of liposomal composition, Drug Delivery 2001; 8:231–237
22. Jesorka A, al., Liposomes: technologies and analytical applications, Annu. Rev. Anal. Chem. 1 (2008) 801–832
23. Vemuri S, et al., Preparation and characterization of liposomes as therapeutic delivery systems: a review, Pharm. Acta Helv. 1995; 70:95–111
24. James ND, et al., Liposomes doxorubicin (Doxil): an effective new treatment for Kaposi’s sarcoma in AIDS, Clin. Oncol.(R. Coll. Radiol.) 1994; 6(5):294–296
25. Laouini A et al., Preparation, characterization and applications of liposomes: state of the art, J. Colloid Sci. Biotechnol. 2012; 1:147–168.
26. Gregoriadis G, et al., Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells, Biochem. Biophys. Res. Commun. 1979; 89:1287–1293.
27. Shailesh S, Neelam S, Sandeep K, Gupta GD, Liposomes: A review, Journal of Pharmacy Research 2009; 2(7):1163-1167.
28. Deshmukh RR, Gawale SV, Bhagwat MK, Ahire PA, Derle ND, A Review on: liposomes, World journal of pharmacy and pharmaceutical sciences, Issue 03, 506-517.
29. Godbole MD, Mathur VB, Selection of phospholipid and method of formulation for optimum entrapment and release of lamivudine from liposome. Journal of Drug Delivery and Therapeutics, 2018; 8(5-s):175-183. https://doi.org/10.22270/jddt.v8i5-s.1935
30. John DF, Yunus AA, Chigbo UJ, Paul US, Ikenna E. Tolnaftate loaded liposomes-design, and in-vitro evaluation. Universal Journal of Pharmaceutical Research. 2016; 1(2): 48-53.
31. Anwekar H, Patel S, Singhai AK, Liposomes as drug carriers , International journal of Pharmacy and life sciences, July 2011.
32. Dwivedi C, Yadav R, Tiwari SP, Satapathy T, Roy A, Role of liposomes in novel drug delivery system, Journal of drug delivery and therapeutics 2014; 4(2):116-129.
33. Priyanka R Kulkarni, Jaydeep D Yadav, Kumar A Vaidya. Liposomes: A Novel Drug Delivery System. International journal of current Pharmaceutical and Research 2011; 3(2).
34. Yadav Y, Kumar S , Pandey D, Dutta RK, Liposomes for drug delivery ,Journal of Biotechnology and Biomaterials , 2017.
35. Ugochukwu AE, Nnedimkpa OJ, Rita NO. Preparation and characterization of Tolterodine tartrate proniosomes, Universal Journal of Pharmaceutical Research. 2017; 2(2):22-25.
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Mishra H, Chauhan V, Kumar K, Teotia D. A comprehensive review on Liposomes: a novel drug delivery system. JDDT [Internet]. 25Nov.2018 [cited 2Feb.2023];8(6):400-4. Available from: http://jddtonline.info/index.php/jddt/article/view/2071
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