A COMPARATIVE STUDY OF EFFICACY AND SAFETY OF DICLOFENAC AND ACECLOFENAC IN THE TREATMENT OF OSTEOARTHRITIS PATIENTS
Objectives: Osteoarthritis is a slowly evolving, active disease of degeneration of the articular cartilage associated with symptoms of joint pain, stiffness and limitation of movement. Typically, these symptoms tend to worse with weight bearing and activity. Non-steroidal anti-inflammatory drugs play an important role in the management of osteoarthritis. This study was conducted to compare efficacy and safety of Aceclofenac and Diclofenac in the treatment of osteoarthritis patient.
Design: Randomized, single blinded, parallel group clinical study
Intervention: The study was conducted in 140 patients of OA. After initial clinical assessment and baseline investigations, Aceclofenac was prescribed to 70 patients and Diclofenac to another 70 patients for 8 weeks. At follow-up, the patients were re-evaluated and compared statistically.
Main outcome measures: were Western Ontario MacMaster (WOMAC) scores, time taken to walk 100 feet, visual analogue scores for pain, investigators assessment for disease status and response to therapy, patient response to drug and joint tenderness. Safety assessment was based on adverse events.
Results: Aceclofenac significantly improved patientâ€™s clinical condition from baseline to day 56. Aceclofenac was found to be superior to Diclofenac in efficacy parameters of WOMAC osteoarthritis index scores (p<0.0001), joint tenderness (p<0.0001), investigator assessment for disease status (p=0.01) and response to therapy (p=0.038), patient response to drug (p=0.024). Aceclofenac and Diclofenac were equally effective in other efficacy parameters. Aceclofenac was found well tolerated than Diclofenac in terms of epigastric discomfort, dyspepsia and abdominal pain.
Conclusion: Aceclofenac is a better choice in osteoarthritis in comparison to Diclofenac due to its better efficacy and safety.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).